Reactome | p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB

Schema > Reaction > Entries

p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB Show undefined attributes

catalystActivity	[CatalystActivity:10352686] protein serine/threonine kinase activity of CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10352688
displayName	p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB
eventOf	[Pathway:R-BTA-2871837] FCERI mediated NF-kB activation - Bos taurus [Pathway:R-BTA-5607764] CLEC7A (Dectin-1) signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-193691] NF-kB migrates to the nucleus and turns on transcription - Bos taurus
inferredFrom	[Reaction:R-HSA-202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-193938] IkB(alpha):NF-kB complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-BTA-5607671] p-S32,36-IkB-alpha:NF-kB complex [cytosol]
precedingEvent	[BlackBoxEvent:R-BTA-202534] Ubiquitination of NEMO by TRAF6 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-202541
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-5607764] CLEC7A (Dectin-1) signaling [Pathway:R-BTA-2871837] FCERI mediated NF-kB activation [Pathway:R-BTA-202424] Downstream TCR signaling
(precedingEvent)	[Reaction:R-BTA-193691] NF-kB migrates to the nucleus and turns on transcription
(inferredTo)	[Reaction:R-HSA-202541] p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB

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