ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))

Stable Identifier
R-HSA-2022405
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Angiotensin-converting Enzyme Hydrolyzes Angiotensin I to Yield Angiotensin II
ReviewStatus
5/5
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Angiotensin-converting enzyme (ACE) hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-8) (angiotensin II) (Ehlers and Kirsch 1988). ACE is found at the plasma membrane of endothelial cells. This reaction is inhibited by drugs used to treat hypertension (angiotensin converting enzyme inhibitors, ACEI) including captopril (Gronhagen-Riska and Fyhrquist 1980, Stewart et al. 1981, Ehlers et al. 1986, Hayakari et al. 1989, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), enalaprilat (metablized from the prodrug enalapril, Wei et al. 1991, Baudin and Beneteau-Burnat 1999), lisinopril ( Ehlers et al. 1991, Natesh et al. 2003), and ramiprilat (metabolized from the prodrug ramipril, Baudin and Beneteau-Burnat 1999).
Literature References
PubMed ID Title Journal Year
1848554 Expression and characterization of recombinant human angiotensin I-converting enzyme. Evidence for a C-terminal transmembrane anchor and for a proteolytic processing of the secreted recombinant and plasma enzymes

Wei, L, Clauser, E, Corvol, P, Soubrier, F, Michaud, A, Alhenc-Gelas, F

J Biol Chem 1991
2558510 Purification of angiotensin-converting enzyme from human intestine

Amano, K, Hayakari, M, Murakami, S, Izumi, H

Adv Exp Med Biol 1989
6270633 Purification and characterization of human converting enzyme (kininase II)

Weare, JA, Erdös, EG, Stewart, TA

Peptides 1981
6269175 Purification of human lung angiotensin-converting enzyme

Fyhrquist, F, Grönhagen-Riska, C

Scand J Clin Lab Invest 1980
1668266 Purification and characterization of recombinant human testis angiotensin-converting enzyme expressed in Chinese hamster ovary cells

Chen, YN, Ehlers, MR, Riordan, JF

Protein Expr Purif 1991
12540854 Crystal structure of the human angiotensin-converting enzyme-lisinopril complex

Acharya, KR, Sturrock, ED, Schwager, SL, Natesh, R

Nature 2003
1851160 The two homologous domains of human angiotensin I-converting enzyme are both catalytically active

Wei, L, Clauser, E, Corvol, P, Alhenc-Gelas, F

J Biol Chem 1991
10536878 Mixed-type inhibition of pulmonary angiotensin I-converting enzyme by captopril, enalaprilat and ramiprilat

Bénéteau-Burnat, B, Baudin, B

J Enzyme Inhib 1999
3017438 Rapid affinity chromatographic purification of human lung and kidney angiotensin-converting enzyme with the novel N-carboxyalkyl dipeptide inhibitor N-[1(S)-carboxy-5-aminopentyl]glycylglycine

Kirsch, RE, Maeder, DL, Ehlers, MR

Biochim Biophys Acta 1986
2846041 Catalysis of angiotensin I hydrolysis by human angiotensin-converting enzyme: effect of chloride and pH

Kirsch, RE, Ehlers, MR

Biochemistry 1988
Participants
Participates
Event Information
Go Biological Process
Catalyst Activity

metallodipeptidase activity of ACE(30-1306):Zn2+ [plasma membrane]

This event is regulated
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Orthologous Events
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