Autocatalytic phosphorylation of FGFR4 Y367C mutant

Stable Identifier
R-HSA-2012087
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Expression of the FGFR4 Y367C mutant in MDA-MB453 breast cancer cell line results in constitutive tyrosine phosphorylation of the receptor and serum-independent activation of downstream signaling as monitored by Erk phosphorylation. Ectopic expression of FGFR4 Y367C in HEK cells also leads to Erk activation and enhanced cellular proliferation. Akt and phospho-AKT levels were not affected by overexpression of the FGFR4 Y367C mutant, however (Roidl, 2010)

Literature References
PubMed ID Title Journal Year
19946327 The FGFR4 Y367C mutant is a dominant oncogene in MDA-MB453 breast cancer cells

Roidl, A, Foo, P, Wong, W, Mann, C, Bechtold, S, Berger, HJ, Streit, S, Ruhe, JE, Hart, S, Ullrich, A, Ho, HK

Oncogene 2010
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of FGFR4 Y367C mutant dimer [plasma membrane]

Normal reaction
Functional status

Gain of function of FGFR4 Y367C mutant dimer [plasma membrane]

Status
Disease
Name Identifier Synonyms
breast cancer DOID:1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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