Reactome | Autocatalytic phosphorylation of FGFR3c P250R mutant

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Autocatalytic phosphorylation of FGFR3c P250R mutant Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:2012066] protein tyrosine kinase activity of FGFR3c P250R mutant dimer bound to FGF [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2012075] Rothfels, K, 2011-11-22
dbId	2012073
disease	[Disease:2011822] acrocephalosyndactylia [Disease:2011847] craniosynostosis [Disease:2032940] bone development disease
displayName	Autocatalytic phosphorylation of FGFR3c P250R mutant
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654464] gain_of_function of FGFR3c P250R mutant dimer bound to FGF [plasma membrane]
eventOf	[Pathway:R-HSA-1839130] Signaling by activated point mutants of FGFR3 - Homo sapiens
input	12 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2011952] FGFR3c P250R mutant dimer bound to FGF [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2011820] Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autocatalytic phosphorylation of FGFR3c P250R mutant
output	[Complex:R-HSA-2011989] Activated FGFR3c P250R mutant [plasma membrane] 12 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-2012074] FGFR3c P250R mutant binds to ligand with enhanced affinity - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2012073
summation	[Summation:2064283] After high-affinity ligand binding, FGFR3 P250R is believed ...

Referrals

(hasEvent)

[Pathway:R-HSA-1839130] Signaling by activated point mutants of FGFR3

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