Reactome | 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate

Schema > Reaction > Entries

5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate Show undefined attributes

catalystActivity	[CatalystActivity:10928153] methenyltetrahydrofolate cyclohydrolase activity of MTHFD1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10928193
displayName	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate
eventOf	[Pathway:R-CEL-196757] Metabolism of folate and pterines - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate - Homo sapiens
input	[SimpleEntity:R-ALL-200640] 5,10-methenyl-THFPG [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate
output	[SimpleEntity:R-ALL-111353] 10-formyl-THFPG [cytosol]
precedingEvent	[Reaction:R-CEL-200644] 5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-200740
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-CEL-6808496] ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG
(inferredTo)	[Reaction:R-HSA-200740] 5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate

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