Reactome | SLC46A1 transports FOLA from extracellular region to cytosol

Schema > Reaction > Entries

SLC46A1 transports FOLA from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10003493] folic acid:proton symporter activity of SLC46A1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10003539
displayName	SLC46A1 transports FOLA from extracellular region to cytosol
eventOf	[Pathway:R-MMU-196757] Metabolism of folate and pterines - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-197963] DHFR2 reduces FOLA to DHF - Mus musculus [Reaction:R-MMU-9709098] DHFR dimer reduces FOLA to DHF - Mus musculus
inferredFrom	[Reaction:R-HSA-200729] SLC46A1 transports FOLA from extracellular region to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-200716] FOLA [extracellular region] [SimpleEntity:R-ALL-351626] H+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC46A1 transports FOLA from extracellular region to cytosol Extracellular folate import across the plasma membrane
output	[SimpleEntity:R-ALL-197965] FOLA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-200729
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-MMU-197963] DHFR2 reduces FOLA to DHF [Reaction:R-MMU-9709098] DHFR dimer reduces FOLA to DHF
(inferredTo)	[Reaction:R-HSA-200729] SLC46A1 transports FOLA from extracellular region to cytosol

Cite Us!