Reactome | FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG

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FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG Show undefined attributes

catalystActivity	[CatalystActivity:10927355] tetrahydrofolylpolyglutamate synthase activity of FPGS-2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10928175
displayName	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG
eventOf	[Pathway:R-CEL-196757] Metabolism of folate and pterines - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-174374] MTR transfers CH3 from MeCbl to HCYS - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG - Homo sapiens
input	[SimpleEntity:R-ALL-200665] 5-methyl-THF [cytosol] 5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] 5 × [SimpleEntity:R-ALL-29404] L-Glu [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate
output	[SimpleEntity:R-ALL-174404] 5-methyl-THFPG [cytosol] 5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] 5 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-CEL-200652] SLC19A1 transports 5-methyl-THF from extracellular region to cytosol - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-200681
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-CEL-174374] MTR transfers CH3 from MeCbl to HCYS
(inferredTo)	[Reaction:R-HSA-200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG

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