Reactome | MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG

Schema > Reaction > Entries

MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG Show undefined attributes

catalystActivity	[CatalystActivity:10466042] methylenetetrahydrofolate reductase [NAD(P)H] activity of MTHFR dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10466044
displayName	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG
eventOf	[Pathway:R-SSC-196757] Metabolism of folate and pterines - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-174374] MTR transfers CH3 from MeCbl to HCYS - Sus scrofa
inferredFrom	[Reaction:R-HSA-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG - Homo sapiens
input	[SimpleEntity:R-ALL-200739] 5,10-methylene-THFPG [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG 5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+
output	[SimpleEntity:R-ALL-174404] 5-methyl-THFPG [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-SSC-200718] MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG - Sus scrofa [Reaction:R-SSC-200735] SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-200676
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-196757] Metabolism of folate and pterines
(precedingEvent)	[Reaction:R-SSC-174374] MTR transfers CH3 from MeCbl to HCYS
(inferredTo)	[Reaction:R-HSA-200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG

Cite Us!