Reactome | CPT1A transfers PALM to CAR

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CPT1A transfers PALM to CAR Show undefined attributes

authored	[InstanceEdit:201063] Gopinathrao, G, 2007-07-29 21:03:03
catalystActivity	[CatalystActivity:201041] carnitine O-palmitoyltransferase activity of CPT1A [mitochondrial outer membrane]
catalystActivityReference	[CatalystActivityReference:9911360] carnitine O-palmitoyltransferase activity of CPT1A [mitochondrial outer membrane] Functional and structural basis of carnitine palmitoyltransferase 1A deficiency
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane [Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:200415] Gopinathrao, G, 2007-07-18 19:50:24
crossReference	[DatabaseIdentifier:12667828] RHEA:12661 [DatabaseIdentifier:9911369] RHEA:12662
dbId	200406
displayName	CPT1A transfers PALM to CAR
edited	[InstanceEdit:200415] Gopinathrao, G, 2007-07-18 19:50:24
eventOf	[Pathway:R-HSA-200425] Carnitine shuttle - Homo sapiens
followingEvent	[Reaction:R-HSA-200424] Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane - Homo sapiens
input	[SimpleEntity:R-ALL-549207] CAR [mitochondrial intermembrane space] [SimpleEntity:R-ALL-200993] PALM-CoA [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:201014] Functional and structural basis of carnitine palmitoyltransferase 1A deficiency [LiteratureReference:549206] Molecular basis of hepatic carnitine palmitoyltransferase I deficiency [LiteratureReference:201018] Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain [LiteratureReference:549204] Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal [LiteratureReference:201072] Structure-function relationships of the liver and muscle isoforms of carnitine palmitoyltransferase I [LiteratureReference:549202] Functional studies of yeast-expressed human heart muscle carnitine palmitoyltransferase I [LiteratureReference:5423014] Induction of carnitine palmitoyl transferase 1 and fatty acid oxidation by retinoic acid in HepG2 cells
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	CPT1A transfers PALM to CAR palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH (R)-carnitine + hexadecanoyl-CoA => CoA + O-hexadecanoyl-(R)-carnitine
orthologousEvent	[Reaction:R-CFA-200406] CPT1A transfers PALM to CAR - Canis familiaris [Reaction:R-CEL-200406] CPT1A transfers PALM to CAR - Caenorhabditis elegans [Reaction:R-DME-200406] CPT1A transfers PALM to CAR - Drosophila melanogaster [Reaction:R-GGA-200406] CPT1A transfers PALM to CAR - Gallus gallus [Reaction:R-DRE-200406] CPT1A transfers PALM to CAR - Danio rerio [Reaction:R-SSC-200406] CPT1A transfers PALM to CAR - Sus scrofa [Reaction:R-BTA-200406] CPT1A transfers PALM to CAR - Bos taurus [Reaction:R-RNO-200406] CPT1A transfers PALM to CAR - Rattus norvegicus [Reaction:R-MMU-200406] CPT1A transfers PALM to CAR - Mus musculus
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-201034] L-PCAR [mitochondrial intermembrane space]
precedingEvent	[BlackBoxEvent:R-HSA-8949399] CAR translocates from the cytosol to the mitochondrial intermembrane space - Homo sapiens [Reaction:R-HSA-434382] ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A - Homo sapiens [Reaction:R-HSA-5634100] FABP5 dissociates from RXRA:PPARD:atRA - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-200418] Negative regulation by 'Mal-CoA [cytosol]' [PositiveRegulation:R-HSA-5422944] Positive regulation by 'RXRA:PPARD:atRA [nucleoplasm]'
regulationReference	[RegulationReference:9642880] Negative regulation by 'Mal-CoA [cytosol]' Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:201322] D'Eustachio, P, 2007-07-31 18:50:15
revised	[InstanceEdit:5423020] Jassal, Bijay, 2014-05-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-200406
summation	[Summation:201082] Carnitine palmitoyl transferase 1A (CPT1A) associated with t...
updateTrackers	[UpdateTracker:9782707] Update Tracker - [Reaction:200406] CPT1A,B transfers PALM to CAR - v58:[modifyText] [UpdateTracker:9785556] Update Tracker - [Reaction:200406] CPT1A,B transfers PALM to CAR - v51:[add_removeRegulator] [UpdateTracker:9790681] Update Tracker - [Reaction:200406] CPT1A,B transfers PALM to CAR - v33:[addInput, addOutput, add_removeLiteratureReference, modifyText] [UpdateTracker:9777640] Update Tracker - [Reaction:200406] CPT1A,B transfers PALM to CAR - v70:[modifyText] [UpdateTracker:9786598] Update Tracker - [Reaction:200406] CPT1A,B transfers PALM to CAR - v49:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9919369] Update Tracker - [Reaction:200406] CPT1A transfers PALM to CAR - v90:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782707] Update Tracker - [Reaction:200406] CPT1A,B transfers PALM to CAR - v58:[modifyText] [UpdateTracker:9785556] Update Tracker - [Reaction:200406] CPT1A,B transfers PALM to CAR - v51:[add_removeRegulator] [UpdateTracker:9790681] Update Tracker - [Reaction:200406] CPT1A,B transfers PALM to CAR - v33:[addInput, addOutput, add_removeLiteratureReference, modifyText] [UpdateTracker:9777640] Update Tracker - [Reaction:200406] CPT1A,B transfers PALM to CAR - v70:[modifyText] [UpdateTracker:9786598] Update Tracker - [Reaction:200406] CPT1A,B transfers PALM to CAR - v49:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9919369] Update Tracker - [Reaction:200406] CPT1A transfers PALM to CAR - v90:[modifyText]
(hasEvent)	[Pathway:R-HSA-200425] Carnitine shuttle
(precedingEvent)	[Reaction:R-HSA-200424] Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane

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