Reactome | CPT1A transfers PALM to CAR

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CPT1A transfers PALM to CAR Show undefined attributes

catalystActivity	[CatalystActivity:10927973] carnitine O-palmitoyltransferase activity of CPT1A [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane [Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10927975
displayName	CPT1A transfers PALM to CAR
eventOf	[Pathway:R-CEL-200425] Carnitine shuttle - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-200424] Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-200406] CPT1A transfers PALM to CAR - Homo sapiens
input	[SimpleEntity:R-ALL-549207] CAR [mitochondrial intermembrane space] [SimpleEntity:R-ALL-200993] PALM-CoA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CPT1A transfers PALM to CAR palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH (R)-carnitine + hexadecanoyl-CoA => CoA + O-hexadecanoyl-(R)-carnitine
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-201034] L-PCAR [mitochondrial intermembrane space]
precedingEvent	[Reaction:R-CEL-434382] ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A - Caenorhabditis elegans
regulatedBy	[NegativeRegulation:R-HSA-200418] Negative regulation by 'Mal-CoA [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-200406
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-200425] Carnitine shuttle
(precedingEvent)	[Reaction:R-CEL-200424] Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane
(inferredTo)	[Reaction:R-HSA-200406] CPT1A transfers PALM to CAR

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