Reactome | CPT1A,B transfers PALM to CAR

Schema > Reaction > Entries

CPT1A,B transfers PALM to CAR Show undefined attributes

catalystActivity	[CatalystActivity:9882911] carnitine O-palmitoyltransferase activity of CPT1A,B [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane [Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9882921
displayName	CPT1A,B transfers PALM to CAR
eventOf	[Pathway:R-MMU-200425] Carnitine metabolism - Mus musculus [Pathway:R-MMU-5362517] Signaling by Retinoic Acid - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-200424] Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane - Mus musculus
inferredFrom	[Reaction:R-HSA-200406] CPT1A,B transfers PALM to CAR - Homo sapiens
input	[SimpleEntity:R-ALL-549207] CAR [mitochondrial intermembrane space] [SimpleEntity:R-ALL-200993] PALM-CoA [cytosol]
isInDisease	false
isInferred	true
name	CPT1A,B transfers PALM to CAR palmitoyl-CoA + carnitine => palmitoylcarnitine + CoASH
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-201034] L-PCARN [mitochondrial intermembrane space]
precedingEvent	[Reaction:R-MMU-434382] ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell - Mus musculus
regulatedBy	[NegativeRegulation:R-HSA-200418] Negative regulation by 'Mal-CoA [cytosol]' [PositiveRegulation:9882922] Positive regulation by 'RXRA:PPARD:atRA [nucleoplasm]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-200406
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5362517] Signaling by Retinoic Acid [Pathway:R-MMU-200425] Carnitine metabolism
(precedingEvent)	[Reaction:R-MMU-200424] Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane
(inferredTo)	[Reaction:R-HSA-200406] CPT1A,B transfers PALM to CAR