Reactome | SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol

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SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol Show undefined attributes

authored	[InstanceEdit:199189] D'Eustachio, P, 2007-07-09 22:03:12
catalystActivity	[CatalystActivity:199212] sodium-dependent multivitamin transmembrane transporter activity of SLC5A6:PDZD11 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:199189] D'Eustachio, P, 2007-07-09 22:03:12
crossReference	[DatabaseIdentifier:12668273] RHEA:73375
dbId	199219
displayName	SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
edited	[InstanceEdit:199189] D'Eustachio, P, 2007-07-09 22:03:12
eventOf	[Pathway:R-HSA-196780] Biotin transport and metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-4167511] HLCS biotinylates ACACB - Homo sapiens [Reaction:R-HSA-2993447] HLCS biotinylates 6x(PCCA:PCCB) - Homo sapiens [Reaction:R-HSA-2993802] HLCS biotinylates PC:Mn2+ - Homo sapiens [Reaction:R-HSA-2993799] HLCS biotinylates 6xMCCC1:6xMCCC2 - Homo sapiens [Reaction:R-HSA-2993814] HLCS biotinylates ACACA:Mn2+ - Homo sapiens
input	[SimpleEntity:R-ALL-199238] Btn [extracellular region] 2 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199231] Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. [LiteratureReference:199217] Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter [LiteratureReference:3076902] Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system [LiteratureReference:5359001] Association of PDZ-containing protein PDZD11 with the human sodium-dependent multivitamin transporter
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol biotin [extracellular] + 2 Na+ [extracellular] => biotin [cytosol] + 2 Na+ [cytosol]
orthologousEvent	[Reaction:R-GGA-199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol - Gallus gallus [Reaction:R-XTR-199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol - Xenopus tropicalis [Reaction:R-DRE-199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol - Danio rerio [Reaction:R-SSC-199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol - Sus scrofa [Reaction:R-BTA-199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol - Bos taurus [Reaction:R-CFA-199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol - Canis familiaris [Reaction:R-RNO-199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol - Rattus norvegicus [Reaction:R-MMU-199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol - Mus musculus
output	[SimpleEntity:R-ALL-199207] Btn [cytosol] 2 × [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2007-09-04
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:3076883] Jassal, B, 2013-02-07 [InstanceEdit:5359004] Jassal, Bijay, 2014-04-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-199219
summation	[Summation:199237] The plasma membrane-associated transport protein SLC5A6 (aka...
updateTrackers	[UpdateTracker:9786385] Update Tracker - [Reaction:199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol - v49:[addLiteratureReference, modifyText] [UpdateTracker:9787890] Update Tracker - [Reaction:199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol - v44:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786385] Update Tracker - [Reaction:199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol - v49:[addLiteratureReference, modifyText] [UpdateTracker:9787890] Update Tracker - [Reaction:199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol - v44:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-196780] Biotin transport and metabolism
(precedingEvent)	[Reaction:R-HSA-4167511] HLCS biotinylates ACACB [Reaction:R-HSA-2993447] HLCS biotinylates 6x(PCCA:PCCB) [Reaction:R-HSA-2993802] HLCS biotinylates PC:Mn2+ [Reaction:R-HSA-2993799] HLCS biotinylates 6xMCCC1:6xMCCC2 [Reaction:R-HSA-2993814] HLCS biotinylates ACACA:Mn2+

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