Reactome | SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol

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SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10351124] sodium-dependent multivitamin transmembrane transporter activity of SLC5A6:PDZD11 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10351135
displayName	SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
eventOf	[Pathway:R-BTA-196780] Biotin transport and metabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-4167511] HLCS biotinylates ACACB - Bos taurus [Reaction:R-BTA-2993447] HLCS biotinylates 6x(PCCA:PCCB) - Bos taurus [Reaction:R-BTA-2993802] HLCS biotinylates PC:Mn2+ - Bos taurus [Reaction:R-BTA-2993799] HLCS biotinylates 6xMCCC1:6xMCCC2 - Bos taurus [Reaction:R-BTA-2993814] HLCS biotinylates ACACA:Mn2+ - Bos taurus
inferredFrom	[Reaction:R-HSA-199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-199238] Btn [extracellular region] 2 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol biotin [extracellular] + 2 Na+ [extracellular] => biotin [cytosol] + 2 Na+ [cytosol]
output	[SimpleEntity:R-ALL-199207] Btn [cytosol] 2 × [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-199219
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-196780] Biotin transport and metabolism
(precedingEvent)	[Reaction:R-BTA-4167511] HLCS biotinylates ACACB [Reaction:R-BTA-2993447] HLCS biotinylates 6x(PCCA:PCCB) [Reaction:R-BTA-2993802] HLCS biotinylates PC:Mn2+ [Reaction:R-BTA-2993799] HLCS biotinylates 6xMCCC1:6xMCCC2 [Reaction:R-BTA-2993814] HLCS biotinylates ACACA:Mn2+
(inferredTo)	[Reaction:R-HSA-199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol

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