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Schema
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Reaction
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Entries
HLCS biotinylates PC:Mn2+
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authored
[InstanceEdit:2993797] Jassal, B, 2013-01-21
catalystActivity
[CatalystActivity:2993868] biotin-protein ligase activity of HLCS [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:2993797] Jassal, B, 2013-01-21
dbId
2993802
displayName
HLCS biotinylates PC:Mn2+
edited
[InstanceEdit:2993797] Jassal, B, 2013-01-21
eventOf
[Pathway:R-HSA-196780] Biotin transport and metabolism - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-3323111] Cytoslic carboxylases translocate to mitochondrial matrix - Homo sapiens
[BlackBoxEvent:R-HSA-3065959] An unknown protease degrades hCBXs - Homo sapiens
input
[Complex:R-HSA-2993798] 4x(PC:Mn2+) [cytosol]
4 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
4 ×
[SimpleEntity:R-ALL-199207] Btn [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:2993855] Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction
[LiteratureReference:2993882] Mutations in the holocarboxylase synthetase gene HLCS
[LiteratureReference:3323165] Holocarboxylase synthetase: correlation of protein localisation with biological function
[LiteratureReference:3323129] Identification of holocarboxylase synthetase (HCS) proteins in human placenta
[LiteratureReference:3323162] Selectivity in post-translational biotin addition to five human carboxylases
modified
[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name
HLCS biotinylates PC:Mn2+
orthologousEvent
[Reaction:R-SCE-2993802] HLCS biotinylates PC:Mn2+ - Saccharomyces cerevisiae
[Reaction:R-SPO-2993802] HLCS biotinylates PC:Mn2+ - Schizosaccharomyces pombe
[Reaction:R-CEL-2993802] HLCS biotinylates PC:Mn2+ - Caenorhabditis elegans
[Reaction:R-DME-2993802] HLCS biotinylates PC:Mn2+ - Drosophila melanogaster
[Reaction:R-XTR-2993802] HLCS biotinylates PC:Mn2+ - Xenopus tropicalis
[Reaction:R-SSC-2993802] HLCS biotinylates PC:Mn2+ - Sus scrofa
[Reaction:R-BTA-2993802] HLCS biotinylates PC:Mn2+ - Bos taurus
[Reaction:R-CFA-2993802] HLCS biotinylates PC:Mn2+ - Canis familiaris
[Reaction:R-RNO-2993802] HLCS biotinylates PC:Mn2+ - Rattus norvegicus
[Reaction:R-MMU-2993802] HLCS biotinylates PC:Mn2+ - Mus musculus
output
[Complex:R-HSA-3323188] 4x(Btn-PC:Mn2+) [cytosol]
4 ×
[SimpleEntity:R-ALL-76577] AMP [cytosol]
4 ×
[SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent
[Reaction:R-HSA-199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol - Homo sapiens
releaseDate
2013-06-11
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:3288227] D'Eustachio, P, 2013-04-15
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2993802
summation
[Summation:2993849] Biotin (Btn) acts as a coenzyme to 4 carboxylases which exis...
Referrals
(precedingEvent)
[BlackBoxEvent:R-HSA-3323111] Cytoslic carboxylases translocate to mitochondrial matrix
[BlackBoxEvent:R-HSA-3065959] An unknown protease degrades hCBXs
(hasEvent)
[Pathway:R-HSA-196780] Biotin transport and metabolism
(normalReaction)
[FailedReaction:R-HSA-9035988] Defective HLCS does not biotinylate PC:Mn2+
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