Reactome | HLCS biotinylates ACACA:Mn2+

Schema > Reaction > Entries

HLCS biotinylates ACACA:Mn2+ Show undefined attributes

authored	[InstanceEdit:2993841] Jassal, B, 2013-01-21
catalystActivity	[CatalystActivity:2993868] biotin--[biotin carboxyl-carrier protein] ligase activity of HLCS [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2993841] Jassal, B, 2013-01-21
dbId	2993814
diseaseReaction	[FailedReaction:R-HSA-3323184] Defective HLCS does not biotinylate ACACA:Mn2+ - Homo sapiens
displayName	HLCS biotinylates ACACA:Mn2+
edited	[InstanceEdit:2993841] Jassal, B, 2013-01-21
eventOf	[Pathway:R-HSA-196780] Biotin transport and metabolism - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-3065958] An unknown protease degrades ACACA - Homo sapiens
input	[Complex:R-HSA-2993826] ACACA:2Mn2+ [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-199207] Btn [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2993882] Mutations in the holocarboxylase synthetase gene HLCS [LiteratureReference:3323165] Holocarboxylase synthetase: correlation of protein localisation with biological function [LiteratureReference:3323129] Identification of holocarboxylase synthetase (HCS) proteins in human placenta [LiteratureReference:3323162] Selectivity in post-translational biotin addition to five human carboxylases [LiteratureReference:201319] The subcellular localization of acetyl-CoA carboxylase 2 [LiteratureReference:201031] Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms [LiteratureReference:4167499] Expression and characterization of recombinant fungal acetyl-CoA carboxylase and isolation of a soraphen-binding domain
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	HLCS biotinylates ACACA:Mn2+
orthologousEvent	[Reaction:R-PFA-2993814] HLCS biotinylates ACACA:Mn2+ - Plasmodium falciparum [Reaction:R-SCE-2993814] HLCS biotinylates ACACA:Mn2+ - Saccharomyces cerevisiae [Reaction:R-SPO-2993814] HLCS biotinylates ACACA:Mn2+ - Schizosaccharomyces pombe [Reaction:R-DDI-2993814] HLCS biotinylates ACACA:Mn2+ - Dictyostelium discoideum [Reaction:R-CEL-2993814] HLCS biotinylates ACACA:Mn2+ - Caenorhabditis elegans [Reaction:R-DME-2993814] HLCS biotinylates ACACA:Mn2+ - Drosophila melanogaster [Reaction:R-GGA-2993814] HLCS biotinylates ACACA:Mn2+ - Gallus gallus [Reaction:R-XTR-2993814] HLCS biotinylates ACACA:Mn2+ - Xenopus tropicalis [Reaction:R-SSC-2993814] HLCS biotinylates ACACA:Mn2+ - Sus scrofa [Reaction:R-BTA-2993814] HLCS biotinylates ACACA:Mn2+ - Bos taurus [Reaction:R-CFA-2993814] HLCS biotinylates ACACA:Mn2+ - Canis familiaris [Reaction:R-RNO-2993814] HLCS biotinylates ACACA:Mn2+ - Rattus norvegicus [Reaction:R-MMU-2993814] HLCS biotinylates ACACA:Mn2+ - Mus musculus
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [Complex:R-HSA-2993815] Btn-ACACA:2Mn2+ [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-199219] SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol - Homo sapiens [BlackBoxEvent:R-HSA-163743] Transcriptional activation of ACACA by ChREBP:MLX - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3288227] D'Eustachio, P, 2013-04-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2993814
summation	[Summation:2993844] Biotin (Btn) acts as a coenzyme for 5 carboxylases that exis...
updateTrackers	[UpdateTracker:9787186] Update Tracker - [Reaction:2993814] HLCS biotinylates ACACA:Mn2+ - v46:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787186] Update Tracker - [Reaction:2993814] HLCS biotinylates ACACA:Mn2+ - v46:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-196780] Biotin transport and metabolism
(precedingEvent)	[BlackBoxEvent:R-HSA-3065958] An unknown protease degrades ACACA
(normalReaction)	[FailedReaction:R-HSA-3323184] Defective HLCS does not biotinylate ACACA:Mn2+

Cite Us!