Reactome | PI3K/AKT activation

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PI3K/AKT activation Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10648620
displayName	PI3K/AKT activation
eventOf	[Pathway:R-DRE-187037] Signaling by NTRK1 (TRKA) - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:172430] phosphatidylinositol 3-kinase/protein kinase B signal transduction
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-198315] Active IRS recruits PI3K to the plasma membrane and activates it - Danio rerio [BlackBoxEvent:R-DRE-198266] PI3K produces PIP3 and other phosphatidyl inositides - Danio rerio [Reaction:R-DRE-202692] PIP3 binds to RhoA and activates it - Danio rerio
inferredFrom	[Pathway:R-HSA-198203] PI3K/AKT activation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	PI3K/AKT activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-198203
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-187037] Signaling by NTRK1 (TRKA)
(inferredTo)	[Pathway:R-HSA-198203] PI3K/AKT activation

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