ARRB mediates NOTCH1 ubiquitination

Stable Identifier
R-HSA-1980118
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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ARRB mediates NOTCH1 ubiquitination
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Ubiquitination of NOTCH1 mediated by DTX-recruited beta-arrestins (ARRB) has not been directly studied in mammals. Non-visual beta arrestins ARRB1 and ARRB2 are known to facilitate ubiquitination and downregulation of GPCRs and IGF1R.

Literature References
PubMed ID Title Journal Year
16284625 Regulation of Notch signalling by non-visual beta-arrestin

Mukherjee, A, Veraksa, A, Bauer, A, Rosse, C, Camonis, J, Artavanis-Tsakonas, S

Nat Cell Biol 2005
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of Ubiquitin ligase [cytosol]
Physical Entity
Ubiquitin ligase [cytosol]
Activity
ubiquitin-protein transferase activity (0004842)
Inferred From
Kurtz promotes ubiquitination of Notch (Drosophila melanogaster)
Authored
Egan, SE  (2011-11-14)
Orlic-Milacic, M  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-09)