Ubiquitination of NOTCH1 mediated by DTX-recruited beta-arrestins (ARRB) has not been directly studied in mammals. Non-visual beta arrestins ARRB1 and ARRB2 are known to facilitate ubiquitination and downregulation of GPCRs and IGF1R.
Mukherjee, A, Veraksa, A, Bauer, A, Rosse, C, Camonis, J, Artavanis-Tsakonas, S
© 2021 Reactome