Binding of NOTCH1 to CNTN1 (contactin-1) is followed by gamm...

created [InstanceEdit:2065909] Orlic-Milacic, M, 2012-01-24
dbId 2065910
displayName Binding of NOTCH1 to CNTN1 (contactin-1) is followed by gamm...
modified [InstanceEdit:2152408] Orlic-Milacic, M, 2012-02-27
schemaClass Summation
text Binding of NOTCH1 to CNTN1 (contactin-1) is followed by gamma-secretase mediated cleavage of NOTCH1 at the S3 cleavage site and accumulation of NICD1 in the nucleus. Cleavage of NOTCH1 by ADAM10/17 at the S2 cleavage site, which should precede the S3 cleavage by gamma-secretase, has not been studied in the context of NOTCH1 activation by CNTN1. NOTCH activation by CNTN1 is deltex-dependent, but the exact mechanism for action of the NOTCH:DTX complex has not yet been elucidated.
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