Reactome | Cleavage of CNTN1:NOTCH1 complex releases NICD1

Cleavage of CNTN1:NOTCH1 complex releases NICD1

Stable Identifier

R-HSA-1980109

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Cleavage of CNTN1:NOTCH1 complex releases NICD1

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Binding of NOTCH1 to CNTN1 (contactin-1) is followed by gamma-secretase mediated cleavage of NOTCH1 at the S3 cleavage site and accumulation of NICD1 in the nucleus. Cleavage of NOTCH1 by ADAM10/17 at the S2 cleavage site, which should precede the S3 cleavage by gamma-secretase, has not been studied in the context of NOTCH1 activation by CNTN1. NOTCH activation by CNTN1 is deltex-dependent, but the exact mechanism for action of the NOTCH:DTX complex has not yet been elucidated.

Literature References

PubMed ID	Title	Journal	Year
14567914	F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation Small, D, Cui, XY, Ling, EA, Hirai, H, Pallen, CJ, Okano, H, Karsak, M, Xiao, ZC, Maciag, T, Ang, BT, Takeda, Y, Watanabe, K, Duka, T, Ng, YK, Hu, QD, Nakafuku, M, Sankar, N, Aster, JC, Chiba, S, Kopan, R, Schachner, M, Trifonova, R, Chia, W, Hu, WP	Cell	2003