NOTCH1 binds JAG1

Stable Identifier
R-HSA-1980042
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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NOTCH1 binds JAG1
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NOTCH1 is activated by JAG1 ligand expressed on a neighboring cell. Based on mouse studies, activation of NOTCH1 by JAG1 may be important in angiogenesis (Benedito et al. 2009). In addition, human JAG1 was shown to inhibit granulocytic differentiation of 32D mouse myeloid progenitors expressing Notch1 (Li et al. 1998).
Literature References
PubMed ID Title Journal Year
9462510 The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1

Friedman, C, Marcovina, S, Banta, AB, Torok-Storb, B, Deng, Y, Hood, L, Li, L, Trask, BJ, Graf, L, Milner, LA, Iwata, M

Immunity 1998
19524514 The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

Benedito, R, Adams, S, Gossler, A, Adams, RH, Fruttiger, M, Roca, C, Sörensen, I

Cell 2009
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
Inferred From
Notch1 binds Jag1 (Mus musculus)
Authored
Jassal, B  (2004-12-15)
Reviewed
Joutel, A  (2004-12-15)
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-09)
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