NOTCH1 is activated by JAG1 ligand expressed on a neighboring cell. Based on mouse studies, activation of NOTCH1 by JAG1 may be important in angiogenesis (Benedito et al. 2009). In addition, human JAG1 was shown to inhibit granulocytic differentiation of 32D mouse myeloid progenitors expressing Notch1 (Li et al. 1998).
Benedito, R, Roca, C, Sörensen, I, Adams, S, Gossler, A, Fruttiger, M, Adams, RH
Li, L, Milner, LA, Deng, Y, Iwata, M, Banta, AB, Graf, L, Marcovina, S, Friedman, C, Trask, BJ, Hood, L, Torok-Storb, B
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