Reactome | 2xTPK1:Mg2+ phosphorylates THMN

Schema > Reaction > Entries

2xTPK1:Mg2+ phosphorylates THMN Show undefined attributes

catalystActivity	[CatalystActivity:196957] thiamine diphosphokinase activity of 2xTPK1:Mg2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
crossReference	[DatabaseIdentifier:12668276] RHEA:11577
dbId	196761
displayName	2xTPK1:Mg2+ phosphorylates THMN
eventOf	[Pathway:R-HSA-196819] Vitamin B1 (thiamin) metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-997381] TDPK phosphorylates ThDP to ThTP - Homo sapiens [Reaction:R-HSA-8875838] SLC25A19 transports ThDP from cytosol to mitochondrial matrix - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-196934] THMN [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:196961] Isolation and characterization of a human thiamine pyrophosphokinase cDNA [LiteratureReference:196958] Molecular cloning of human thiamin pyrophosphokinase
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	2xTPK1:Mg2+ phosphorylates THMN Thiamin is pyrophosphorylated
orthologousEvent	[Reaction:R-PFA-196761] 2xTPK1:Mg2+ phosphorylates THMN - Plasmodium falciparum [Reaction:R-SCE-196761] 2xTPK1:Mg2+ phosphorylates THMN - Saccharomyces cerevisiae [Reaction:R-SPO-196761] 2xTPK1:Mg2+ phosphorylates THMN - Schizosaccharomyces pombe [Reaction:R-DDI-196761] 2xTPK1:Mg2+ phosphorylates THMN - Dictyostelium discoideum [Reaction:R-CEL-196761] 2xTPK1:Mg2+ phosphorylates THMN - Caenorhabditis elegans [Reaction:R-DME-196761] 2xTPK1:Mg2+ phosphorylates THMN - Drosophila melanogaster [Reaction:R-GGA-196761] 2xTPK1:Mg2+ phosphorylates THMN - Gallus gallus [Reaction:R-XTR-196761] 2xTPK1:Mg2+ phosphorylates THMN - Xenopus tropicalis [Reaction:R-DRE-196761] 2xTPK1:Mg2+ phosphorylates THMN - Danio rerio [Reaction:R-SSC-196761] 2xTPK1:Mg2+ phosphorylates THMN - Sus scrofa [Reaction:R-BTA-196761] 2xTPK1:Mg2+ phosphorylates THMN - Bos taurus [Reaction:R-CFA-196761] 2xTPK1:Mg2+ phosphorylates THMN - Canis familiaris [Reaction:R-RNO-196761] 2xTPK1:Mg2+ phosphorylates THMN - Rattus norvegicus [Reaction:R-MMU-196761] 2xTPK1:Mg2+ phosphorylates THMN - Mus musculus
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-29480] ThDP [cytosol]
precedingEvent	[Reaction:R-HSA-199626] SLC19A2/3 transport extracellular THMN to cytosol - Homo sapiens
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-196761
summation	[Summation:196944] Cytosolic thiamin pyrophosphokinase (TPK1) catalyzes the rea...
updateTrackers	[UpdateTracker:9787827] Update Tracker - [Reaction:196761] 2xTPK1:Mg2+ phosphorylates THMN - v44:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787827] Update Tracker - [Reaction:196761] 2xTPK1:Mg2+ phosphorylates THMN - v44:[modifyText]
(hasEvent)	[Pathway:R-HSA-196819] Vitamin B1 (thiamin) metabolism
(precedingEvent)	[Reaction:R-HSA-8875838] SLC25A19 transports ThDP from cytosol to mitochondrial matrix [Reaction:R-HSA-997381] TDPK phosphorylates ThDP to ThTP