Reactome | 2xTPK1:Mg2+ phosphorylates THMN

Schema > Reaction > Entries

2xTPK1:Mg2+ phosphorylates THMN Show undefined attributes

catalystActivity	[CatalystActivity:10002242] thiamine diphosphokinase activity of 2xTPK1:Mg2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10002244
displayName	2xTPK1:Mg2+ phosphorylates THMN
eventOf	[Pathway:R-MMU-196819] Vitamin B1 (thiamin) metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8875838] SLC25A19 transports ThDP from cytosol to mitochondrial matrix - Mus musculus
inferredFrom	[Reaction:R-HSA-196761] 2xTPK1:Mg2+ phosphorylates THMN - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-196934] THMN [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	2xTPK1:Mg2+ phosphorylates THMN Thiamin is pyrophosphorylated
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-29480] ThDP [cytosol]
precedingEvent	[Reaction:R-MMU-199626] SLC19A2/3 transport extracellular THMN to cytosol - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-196761
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-196819] Vitamin B1 (thiamin) metabolism
(precedingEvent)	[Reaction:R-MMU-8875838] SLC25A19 transports ThDP from cytosol to mitochondrial matrix
(inferredTo)	[Reaction:R-HSA-196761] 2xTPK1:Mg2+ phosphorylates THMN

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