Reactome | NRP-1 forms a ternary complex with VEGF165 and VEGFR1

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NRP-1 forms a ternary complex with VEGF165 and VEGFR1 Show undefined attributes

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:195420] Gopinathrao, G, 2007-04-06 20:37:55
dbId	195408
displayName	NRP-1 forms a ternary complex with VEGF165 and VEGFR1
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-194306] Neuropilin interactions with VEGF and VEGFR - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-3008773] NRP1 [plasma membrane] 2 × [EntityWithAccessionedSequence:R-HSA-195382] VEGFR2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:195416] VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding [LiteratureReference:195465] Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain [LiteratureReference:195557] Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling [LiteratureReference:195536] The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1 [LiteratureReference:195551] Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	NRP-1 forms a ternary complex with VEGF165 and VEGFR1
orthologousEvent	[Reaction:R-GGA-195408] NRP-1 forms a ternary complex with VEGF165 and VEGFR1 - Gallus gallus [Reaction:R-XTR-195408] NRP-1 forms a ternary complex with VEGF165 and VEGFR1 - Xenopus tropicalis [Reaction:R-DRE-195408] NRP-1 forms a ternary complex with VEGF165 and VEGFR1 - Danio rerio [Reaction:R-SSC-195408] NRP-1 forms a ternary complex with VEGF165 and VEGFR1 - Sus scrofa [Reaction:R-BTA-195408] NRP-1 forms a ternary complex with VEGF165 and VEGFR1 - Bos taurus [Reaction:R-CFA-195408] NRP-1 forms a ternary complex with VEGF165 and VEGFR1 - Canis familiaris [Reaction:R-RNO-195408] NRP-1 forms a ternary complex with VEGF165 and VEGFR1 - Rattus norvegicus [Reaction:R-MMU-195408] NRP-1 forms a ternary complex with VEGF165 and VEGFR1 - Mus musculus
output	[Complex:R-HSA-195419] NRP1:VEGFR2 dimer [plasma membrane]
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:215257] Claesson-Welsh, L, 2008-02-28 00:15:17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-195408
summation	[Summation:195424] Plasma membrane-associated Neuropilin-1 (NRP1) binds vascula...
updateTrackers	[UpdateTracker:9779042] Update Tracker - [Reaction:195408] NRP-1 forms a ternary complex with VEGF165 and VEGFR1 - v66:[modifyText] [UpdateTracker:9787664] Update Tracker - [Reaction:195408] NRP-1 forms a ternary complex with VEGF165 and VEGFR1 - v44:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9779042] Update Tracker - [Reaction:195408] NRP-1 forms a ternary complex with VEGF165 and VEGFR1 - v66:[modifyText] [UpdateTracker:9787664] Update Tracker - [Reaction:195408] NRP-1 forms a ternary complex with VEGF165 and VEGFR1 - v44:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-194306] Neuropilin interactions with VEGF and VEGFR

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