Reactome | NRP-1 forms a ternary complex with VEGF165 and VEGFR1

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10242983
displayName	NRP-1 forms a ternary complex with VEGF165 and VEGFR1
eventOf	[Pathway:R-CFA-194306] Neuropilin interactions with VEGF and VEGFR - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-195408] NRP-1 forms a ternary complex with VEGF165 and VEGFR1 - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-CFA-3008773] NRP1 [plasma membrane] 2 × [EntityWithAccessionedSequence:R-CFA-195382] VEGFR2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	NRP-1 forms a ternary complex with VEGF165 and VEGFR1
output	[Complex:R-CFA-195419] NRP1:VEGFR2 dimer [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-195408
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-194306] Neuropilin interactions with VEGF and VEGFR
(inferredTo)	[Reaction:R-HSA-195408] NRP-1 forms a ternary complex with VEGF165 and VEGFR1

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