NRP-1 forms a ternary complex with VEGF165 and VEGFR1

Stable Identifier
R-HSA-195408
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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NRP-1 forms a ternary complex with VEGF165 and VEGFR1
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Plasma membrane-associated Neuropilin-1 (NRP1) binds vascular endothelial growth factor (VEGF) family members. NRP1 has three distinct extracellular domains, a1a2, b1b2, and c but lacks a distinct intracellular domain. VEGF165 mediates the formation of complexes containing VEGFR-2 and NRP-1, enhancing VEGF165-receptor binding on the endothelial cell membrane (Soker et al. 2002).
Literature References
PubMed ID Title Journal Year
11756651 Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis

Takagi, H, Kemmochi, S, Otani, A, Oh, H, Honda, Y, Uemura, A, Koyama, S

Proc Natl Acad Sci U S A 2002
11986311 Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain

Gasiunas, N, Mamluk, R, Gechtman, Z, Kutcher, ME, Gallagher, J, Klagsbrun, M

J Biol Chem 2002
11948691 VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding

Nomi, M, Soker, S, Takashima, S, Miao, HQ, Klagsbrun, M

J Cell Biochem 2002
16763549 Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling

Tsukamoto, O, Fukushima, T, Seguchi, O, Shintani, Y, Takashima, S, Kato, H, Liao, Y, Yamazaki, S, Sugahara, K, Hori, M, Asano, Y, Yamamoto, H, Kitakaze, M

EMBO J 2006
10842181 The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1

de Vos, AM, Garcia, KC, Fuh, G

J Biol Chem 2000
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Orthologous Events
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NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Gallus gallus)
NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Mus musculus)
NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Rattus norvegicus)
NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Sus scrofa)
NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Claesson-Welsh, L  (2008-02-28)
Created
Gopinathrao, G  (2007-04-07)
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