NRP-1 forms a ternary complex with VEGF165 and VEGFR1

Stable Identifier
R-HSA-195408
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Plasma membrane-associated Neuropilin-1 (NRP1) binds vascular endothelial growth factor (VEGF) family members. NRP1 has three distinct extracellular domains, a1a2, b1b2, and c but lacks a distinct intracellular domain. VEGF165 mediates the formation of complexes containing VEGFR-2 and NRP-1, enhancing VEGF165-receptor binding on the endothelial cell membrane (Soker et al. 2002).

Literature References
PubMed ID Title Journal Year
11756651 Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis

Takagi, H, Kemmochi, S, Otani, A, Oh, H, Honda, Y, Uemura, A, Koyama, S

Proc Natl Acad Sci U S A 2002
11986311 Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain

Gasiunas, N, Mamluk, R, Gechtman, Z, Kutcher, ME, Gallagher, J, Klagsbrun, M

J Biol Chem 2002
11948691 VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding

Nomi, M, Soker, S, Takashima, S, Miao, HQ, Klagsbrun, M

J Cell Biochem 2002
16763549 Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling

Tsukamoto, O, Fukushima, T, Seguchi, O, Shintani, Y, Takashima, S, Kato, H, Liao, Y, Yamazaki, S, Sugahara, K, Hori, M, Asano, Y, Yamamoto, H, Kitakaze, M

EMBO J 2006
10842181 The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1

de Vos, AM, Garcia, KC, Fuh, G

J Biol Chem 2000
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!