VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization

Stable Identifier
R-HSA-194310
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

VEGFR-2 binds VEGF-A, -C, -D, and -E homodimers. VEGFR-2 is the primary mediator of the physiological effects of VEGF-A in angiogenesis, including microvascular permeability, endothelial cell proliferation, invasion, migration, and survival. In endothelial cells, these effects are mediated via activation of a phospholipase gamma-protein kinase C-Raf-MAPK signaling pathway for proliferation and PI3K and focal adhesion kinase for survival and migration. VEGFR-2 is the important receptor among VEGFR protiens and its activation and signaling may be positively or negatively regulated by co-expression and activation of various factors and other VEGF receptors like VEGFR-1 (Hicklin and Ellis 2005).The regulatory events of this receptor will be annotated in subsequent modules.

Literature References
PubMed ID Title Journal Year
11387210 A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells

Takahashi, T, Yamaguchi, S, Chida, K, Shibuya, M

EMBO J 2001
9207067 Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site

Muller, YA, Li, B, Christinger, HW, Wells, JA, Cunningham, BC, de Vos, AM

Proc Natl Acad Sci U S A 1997
1417831 Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

Terman, BI, Dougher-Vermazen, M, Carrion, ME, Dimitrov, D, Armellino, DC, Gospodarowicz, D, Bohlen, P

Biochem Biophys Res Commun 1992
11004490 Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract

Tsai, YJ, Lee, RK, Lin, SP, Chen, YH

Biochim Biophys Acta 2000
7824266 A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF

Seetharam, L, Gotoh, N, Maru, Y, Neufeld, G, Yamaguchi, S, Shibuya, M

Oncogene 1995
9435229 Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

Achen, MG, Jeltsch, M, Kukk, E, Makinen, T, Vitali, A, Wilks, AF, Alitalo, K, Stacker, SA

Proc Natl Acad Sci U S A 1998
8617204 A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases

Joukov, V, Pajusola, K, Kaipainen, A, Chilov, D, Lahtinen, I, Kukk, E, Saksela, O, Kalkkinen, N, Alitalo, K

EMBO J 1996
12881528 Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites

Dixelius, J, Makinen, T, Wirzenius, M, Karkkainen, MJ, Wernstedt, C, Alitalo, K, Claesson-Welsh, L

J Biol Chem 2003
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created