VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization

Stable Identifier
Reaction [binding]
Homo sapiens
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VEGFR-2 binds VEGF-A, -C, -D, and -E homodimers. VEGFR-2 is the primary mediator of the physiological effects of VEGF-A in angiogenesis, including microvascular permeability, endothelial cell proliferation, invasion, migration, and survival. In endothelial cells, these effects are mediated via activation of a phospholipase gamma-protein kinase C-Raf-MAPK signaling pathway for proliferation and PI3K and focal adhesion kinase for survival and migration. VEGFR-2 is the important receptor among VEGFR protiens and its activation and signaling may be positively or negatively regulated by co-expression and activation of various factors and other VEGF receptors like VEGFR-1 (Hicklin and Ellis 2005).The regulatory events of this receptor will be annotated in subsequent modules.
Literature References
PubMed ID Title Journal Year
9207067 Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site

de Vos, AM, Christinger, HW, Muller, YA, Cunningham, BC, Wells, JA, Li, B

Proc Natl Acad Sci U S A 1997
11387210 A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells

Chida, K, Shibuya, M, Takahashi, T, Yamaguchi, S

EMBO J 2001
1417831 Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

Bohlen, P, Dougher-Vermazen, M, Carrion, ME, Armellino, DC, Terman, BI, Gospodarowicz, D, Dimitrov, D

Biochem Biophys Res Commun 1992
11004490 Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract

Tsai, YJ, Lee, RK, Lin, SP, Chen, YH

Biochim Biophys Acta 2000
7824266 A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF

Maru, Y, Seetharam, L, Shibuya, M, Yamaguchi, S, Gotoh, N, Neufeld, G

Oncogene 1995
9435229 Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

Wilks, AF, Alitalo, K, Achen, MG, Kukk, E, Makinen, T, Jeltsch, M, Vitali, A, Stacker, SA

Proc Natl Acad Sci U S A 1998
8617204 A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases

Kalkkinen, N, Lahtinen, I, Alitalo, K, Kaipainen, A, Kukk, E, Chilov, D, Pajusola, K, Saksela, O, Joukov, V

EMBO J 1996
12881528 Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites

Alitalo, K, Karkkainen, MJ, Wirzenius, M, Makinen, T, Dixelius, J, Claesson-Welsh, L, Wernstedt, C

J Biol Chem 2003
Orthologous Events
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