Reactome | VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization

Schema > Reaction > Entries

VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10242787
displayName	VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization
eventOf	[Pathway:R-CFA-195399] VEGF binds to VEGFR leading to receptor dimerization - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-4420117] VEGFR2 autophosphorylates - Canis familiaris
inferredFrom	[Reaction:R-HSA-194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization - Homo sapiens
input	[DefinedSet:R-CFA-195393] VEGFA,C,D dimers [extracellular region] 2 × [EntityWithAccessionedSequence:R-CFA-195382] VEGFR2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization
output	[Complex:R-CFA-215139] VEGFR2:VEGFA,C,D [plasma membrane]
precedingEvent	[Reaction:R-CFA-195378] Homodimerization of VEGF proteins - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-194310
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-195399] VEGF binds to VEGFR leading to receptor dimerization
(precedingEvent)	[Reaction:R-CFA-4420117] VEGFR2 autophosphorylates
(inferredTo)	[Reaction:R-HSA-194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization

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