Reactome | SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol

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SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10001918] bile acid:sodium symporter activity of SLC10A2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10001920
displayName	SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol
eventOf	[Pathway:R-MMU-159418] Recycling of bile acids and salts - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-9733973] Bile salts bind FABP6 - Mus musculus
inferredFrom	[Reaction:R-HSA-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol - Homo sapiens
input	[DefinedSet:R-ALL-192483] bile salts and acids [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol Co-transport (influx) of bile salts and acids and sodium ions by ASBT
output	[DefinedSet:R-ALL-194156] bile salts and acids [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
precedingEvent	[Reaction:R-MMU-5340195] NR1H4 binds DCA, CDCA, LCHA - Mus musculus
regulatedBy	[PositiveRegulation:10001921] Positive regulation by 'NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-194187
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-159418] Recycling of bile acids and salts
(precedingEvent)	[BlackBoxEvent:R-MMU-9733973] Bile salts bind FABP6
(inferredTo)	[Reaction:R-HSA-194187] SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol

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