Reactome | CYP11B2 oxidises 11DCORST to CORST

Schema > Reaction > Entries

CYP11B2 oxidises 11DCORST to CORST Show undefined attributes

authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:5600617] steroid 11-beta-monooxygenase activity of CYP11B2 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:194008] Jassal, B, 2007-03-06 13:54:16
crossReference	[DatabaseIdentifier:9907751] RHEA:46105
dbId	194017
diseaseReaction	[FailedReaction:R-HSA-5600598] Defective CYP11B2 does not oxidise 11DCORST - Homo sapiens
displayName	CYP11B2 oxidises 11DCORST to CORST
edited	[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
eventOf	[Pathway:R-HSA-193993] Mineralocorticoid biosynthesis - Homo sapiens [Pathway:R-HSA-211976] Endogenous sterols - Homo sapiens
followingEvent	[Reaction:R-HSA-193995] CYP11B2 18-hydroxylates CORST to 18HCORST - Homo sapiens
input	[SimpleEntity:R-ALL-193988] 11DCORST [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:194016] Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta) [LiteratureReference:194031] Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	CYP11B2 oxidises 11DCORST to CORST 21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced (adrenodoxin) => corticosterone + H2O + 2 oxidized (adrenodoxin) 11-deoxycorticosterone + NADPH + H+ + O2 => corticosterone + H2O + NADP+
orthologousEvent	[Reaction:R-XTR-194017] CYP11B2 oxidises 11DCORST to CORST - Xenopus tropicalis [Reaction:R-SSC-194017] CYP11B2 oxidises 11DCORST to CORST - Sus scrofa [Reaction:R-BTA-194017] CYP11B2 oxidises 11DCORST to CORST - Bos taurus [Reaction:R-CFA-194017] CYP11B2 oxidises 11DCORST to CORST - Canis familiaris [Reaction:R-RNO-194017] CYP11B2 oxidises 11DCORST to CORST - Rattus norvegicus [Reaction:R-MMU-194017] CYP11B2 oxidises 11DCORST to CORST - Mus musculus
output	[SimpleEntity:R-ALL-194005] CORST [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:R-HSA-193996] 11DCORST translocates from cytosol to mitochondrial matrix - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21 [InstanceEdit:9907185] Hill, David P, 2024-04-04 [InstanceEdit:9917333] Hill, David P, 2024-08-02
revised	[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-194017
summation	[Summation:196358] Cytochrome P450 11B2, mitochondrial (CYP11B2 aka aldosterone...
updateTrackers	[UpdateTracker:9786171] Update Tracker - [Reaction:194017] CYP11B2 oxidises 11DCORST to CORST - v50:[add_removeCatalystActivity, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786171] Update Tracker - [Reaction:194017] CYP11B2 oxidises 11DCORST to CORST - v50:[add_removeCatalystActivity, modifyText]
(normalReaction)	[FailedReaction:R-HSA-5600598] Defective CYP11B2 does not oxidise 11DCORST
(hasEvent)	[Pathway:R-HSA-211976] Endogenous sterols [Pathway:R-HSA-193993] Mineralocorticoid biosynthesis
(precedingEvent)	[Reaction:R-HSA-193995] CYP11B2 18-hydroxylates CORST to 18HCORST

Cite Us!