Reactome | CYP11B2 oxidises 11DCORST to CORST

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CYP11B2 oxidises 11DCORST to CORST Show undefined attributes

catalystActivity	[CatalystActivity:10122703] steroid 11-beta-monooxygenase activity of CYP11B2 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10122705
displayName	CYP11B2 oxidises 11DCORST to CORST
eventOf	[Pathway:R-RNO-193993] Mineralocorticoid biosynthesis - Rattus norvegicus [Pathway:R-RNO-211976] Endogenous sterols - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-193995] CYP11B2 18-hydroxylates CORST to 18HCORST - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-194017] CYP11B2 oxidises 11DCORST to CORST - Homo sapiens
input	[SimpleEntity:R-ALL-193988] 11DCORST [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP11B2 oxidises 11DCORST to CORST 21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced (adrenodoxin) => corticosterone + H2O + 2 oxidized (adrenodoxin) 11-deoxycorticosterone + NADPH + H+ + O2 => corticosterone + H2O + NADP+
output	[SimpleEntity:R-ALL-194005] CORST [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-194017
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-211976] Endogenous sterols [Pathway:R-RNO-193993] Mineralocorticoid biosynthesis
(precedingEvent)	[Reaction:R-RNO-193995] CYP11B2 18-hydroxylates CORST to 18HCORST
(inferredTo)	[Reaction:R-HSA-194017] CYP11B2 oxidises 11DCORST to CORST

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