Reactome | CYP11B2 18-hydroxylates CORST to 18HCORST

Schema > Reaction > Entries

CYP11B2 18-hydroxylates CORST to 18HCORST Show undefined attributes

authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:193967] steroid hydroxylase activity of CYP11B2 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:194008] Jassal, B, 2007-03-06 13:54:16
dbId	193995
displayName	CYP11B2 18-hydroxylates CORST to 18HCORST
edited	[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
eventOf	[Pathway:R-HSA-193993] Mineralocorticoid biosynthesis - Homo sapiens [Pathway:R-HSA-211976] Endogenous sterols - Homo sapiens
followingEvent	[Reaction:R-HSA-193965] CYP11B2 oxidises 18HCORST to ALDO - Homo sapiens
input	[SimpleEntity:R-ALL-194005] CORST [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:194016] Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta) [LiteratureReference:194015] Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism
modified	[InstanceEdit:10486564] Wright, Adam, 2024-03-07
name	CYP11B2 18-hydroxylates CORST to 18HCORST corticosterone + NADPH + H+ + O2 => 18-hydroxycorticosterone + NADP+ + H2O
orthologousEvent	[Reaction:R-XTR-193995] CYP11B2 18-hydroxylates CORST to 18HCORST - Xenopus tropicalis [Reaction:R-SSC-193995] CYP11B2 18-hydroxylates CORST to 18HCORST - Sus scrofa [Reaction:R-BTA-193995] CYP11B2 18-hydroxylates CORST to 18HCORST - Bos taurus [Reaction:R-CFA-193995] CYP11B2 18-hydroxylates CORST to 18HCORST - Canis familiaris [Reaction:R-RNO-193995] CYP11B2 18-hydroxylates CORST to 18HCORST - Rattus norvegicus [Reaction:R-MMU-193995] CYP11B2 18-hydroxylates CORST to 18HCORST - Mus musculus
output	[SimpleEntity:R-ALL-194012] 18HCORST [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-194017] CYP11B2 oxidises 11DCORST to CORST - Homo sapiens
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
revised	[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-193995
summation	[Summation:194004] Corticosterone, NADPH + H+, and O2 react to form 18-hydroxyc...

Referrals

(normalReaction)	[FailedReaction:R-HSA-6785245] Defective CYP11B2 does not oxidise CORST
(hasEvent)	[Pathway:R-HSA-211976] Endogenous sterols [Pathway:R-HSA-193993] Mineralocorticoid biosynthesis
(precedingEvent)	[Reaction:R-HSA-193965] CYP11B2 oxidises 18HCORST to ALDO