CYP11B2 oxidises 11DCORST to CORST

Stable Identifier
R-HSA-194017
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
11-deoxycorticosterone + NADPH + H+ + O2 => corticosterone + H2O + NADP+
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Cytochrome P450 11B2, mitochondrial (CYP11B2 aka aldosterone hydroxylase) is an enzyme necessary for aldosterone biosynthesis via corticosterone (CORST) and 18-hydroxycorticosterone (18HCORST). The 11-beta oxidation of 11-deoxycorticosterone (11DCORST) leads to corticosterone (CORST) and 18-hydroxylation of this leads to 18-hydroxycorticosterone (18HCORST). 18-oxidation of 18HCORST yields aldosterone.

Literature References
PubMed ID Title Journal Year
2592361 Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta)

Mornet, E, Dupont, J, Vitek, A, White, PC

J Biol Chem 1989
1741400 Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans

Kawamoto, T, Mitsuuchi, Y, Toda, K, Yokoyama, Y, Miyahara, K, Miura, S, Ohnishi, T, Ichikawa, Y, Nakao, K, Imura, H, Ulick, S, Shizuta, Y

Proc Natl Acad Sci U S A 1992
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
steroid 11-beta-monooxygenase activity of CYP11B2 [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
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