Reactome | The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA

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The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA Show undefined attributes

category	dissociation
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10122598
displayName	The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
eventOf	[Pathway:R-RNO-193634] Axonal growth inhibition (RHOA activation) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - Homo sapiens
input	[Complex:R-RNO-194481] RHOA:GDP:ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
output	[Complex:R-RNO-194528] ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG [plasma membrane] [Complex:R-RNO-8964174] RHOA:GDP [plasma membrane]
precedingEvent	[Reaction:R-RNO-9012761] The p75NTR:NgR:MDGI binds RHOA-GDI - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-193696
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-193634] Axonal growth inhibition (RHOA activation)
(precedingEvent)	[Reaction:R-RNO-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth
(inferredTo)	[Reaction:R-HSA-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA

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