Reactome | Axonal growth inhibition (RHOA activation)

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Axonal growth inhibition (RHOA activation) Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10223199
displayName	Axonal growth inhibition (RHOA activation)
eventOf	[Pathway:R-RNO-193697] p75NTR regulates axonogenesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:161083] negative regulation of axonogenesis
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-9012761] The p75NTR:NgR:MDGI binds RHOA-GDI - Rattus norvegicus [Reaction:R-RNO-193696] The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA - Rattus norvegicus [Reaction:R-RNO-194518] RhoA is activated by nucleotide exchange and inhibits axonal growth - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-193634] Axonal growth inhibition (RHOA activation) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Axonal growth inhibition (RHOA activation)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-193634
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-193697] p75NTR regulates axonogenesis
(inferredTo)	[Pathway:R-HSA-193634] Axonal growth inhibition (RHOA activation)

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