Reactome | CYP19A1 hydroxylates ANDST to E1

Schema > Reaction > Entries

CYP19A1 hydroxylates ANDST to E1 Show undefined attributes

authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:193170] steroid hydroxylase activity of CYP19A1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:193053] Jassal, B, 2007-02-13 10:16:33
crossReference	[DatabaseIdentifier:9907748] RHEA:38196
dbId	193060
diseaseReaction	[FailedReaction:R-HSA-5601849] Defective CYP19A1 does not convert ANDST to E1 - Homo sapiens
displayName	CYP19A1 hydroxylates ANDST to E1
edited	[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
eventOf	[Pathway:R-HSA-193144] Estrogen biosynthesis - Homo sapiens [Pathway:R-HSA-211976] Endogenous sterols - Homo sapiens
followingEvent	[Reaction:R-HSA-804969] HSD17B1 hydrogenates E1 to EST17b - Homo sapiens
input	[SimpleEntity:R-ALL-193079] ANDST [cytosol] 3 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 3 × [SimpleEntity:R-ALL-29364] NADPH [cytosol] 3 × [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:193081] Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis [LiteratureReference:193115] Structural and functional characterization of human aromatase P-450 gene
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	CYP19A1 hydroxylates ANDST to E1 Androstenedione is converted to estrone by Aromatase (CYP19A1) androst-4-ene-3,17-dione + 3 O2 + 3 reduced (NADPH--hemoprotein reductase) => estrone + formate + 4 H(+) + 4 H2O + 3 oxidized (NADPH--hemoprotein reductase)
orthologousEvent	[Reaction:R-CEL-193060] CYP19A1 hydroxylates ANDST to E1 - Caenorhabditis elegans [Reaction:R-DME-193060] CYP19A1 hydroxylates ANDST to E1 - Drosophila melanogaster [Reaction:R-GGA-193060] CYP19A1 hydroxylates ANDST to E1 - Gallus gallus [Reaction:R-XTR-193060] CYP19A1 hydroxylates ANDST to E1 - Xenopus tropicalis [Reaction:R-DRE-193060] CYP19A1 hydroxylates ANDST to E1 - Danio rerio [Reaction:R-SSC-193060] CYP19A1 hydroxylates ANDST to E1 - Sus scrofa [Reaction:R-BTA-193060] CYP19A1 hydroxylates ANDST to E1 - Bos taurus [Reaction:R-CFA-193060] CYP19A1 hydroxylates ANDST to E1 - Canis familiaris [Reaction:R-RNO-193060] CYP19A1 hydroxylates ANDST to E1 - Rattus norvegicus [Reaction:R-MMU-193060] CYP19A1 hydroxylates ANDST to E1 - Mus musculus
output	[SimpleEntity:R-ALL-193066] E1 [cytosol] 4 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 4 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29460] HCOOH [cytosol] 3 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-193099] CYP17A1 cleaves 17aHPROG to ANDST - Homo sapiens [Reaction:R-HSA-193073] HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21 [InstanceEdit:9917333] Hill, David P, 2024-08-02
revised	[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-193060
summation	[Summation:196396] The conversion of androstenedione (ANDST) to estrone (E1) is...
updateTrackers	[UpdateTracker:9910983] Update Tracker - [Reaction:193060] CYP19A1 hydroxylates ANDST to E1 - v89:[addOutput] [UpdateTracker:9786216] Update Tracker - [Reaction:193060] CYP19A1 hydroxylates ANDST to E1 - v50:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9910983] Update Tracker - [Reaction:193060] CYP19A1 hydroxylates ANDST to E1 - v89:[addOutput] [UpdateTracker:9786216] Update Tracker - [Reaction:193060] CYP19A1 hydroxylates ANDST to E1 - v50:[modifyText]
(hasEvent)	[Pathway:R-HSA-211976] Endogenous sterols [Pathway:R-HSA-193144] Estrogen biosynthesis
(normalReaction)	[FailedReaction:R-HSA-5601849] Defective CYP19A1 does not convert ANDST to E1
(precedingEvent)	[Reaction:R-HSA-804969] HSD17B1 hydrogenates E1 to EST17b

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