Reactome | CYP19A1 hydroxylates ANDST to E1

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CYP19A1 hydroxylates ANDST to E1 Show undefined attributes

catalystActivity	[CatalystActivity:10463847] steroid hydroxylase activity of CYP19A1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10463849
displayName	CYP19A1 hydroxylates ANDST to E1
eventOf	[Pathway:R-SSC-193144] Estrogen biosynthesis - Sus scrofa [Pathway:R-SSC-211976] Endogenous sterols - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-804969] HSD17B1 hydrogenates E1 to EST17b - Sus scrofa
inferredFrom	[Reaction:R-HSA-193060] CYP19A1 hydroxylates ANDST to E1 - Homo sapiens
input	[SimpleEntity:R-ALL-193079] ANDST [cytosol] 3 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 3 × [SimpleEntity:R-ALL-29364] NADPH [cytosol] 3 × [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP19A1 hydroxylates ANDST to E1 Androstenedione is converted to estrone by Aromatase (CYP19A1) androst-4-ene-3,17-dione + 3 O2 + 3 reduced (NADPH--hemoprotein reductase) => estrone + formate + 4 H(+) + 4 H2O + 3 oxidized (NADPH--hemoprotein reductase)
output	[SimpleEntity:R-ALL-193066] E1 [cytosol] 4 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 4 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29460] HCOOH [cytosol] 3 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-SSC-193099] CYP17A1 cleaves 17aHPROG to ANDST - Sus scrofa [Reaction:R-SSC-193073] HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-193060
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-211976] Endogenous sterols [Pathway:R-SSC-193144] Estrogen biosynthesis
(precedingEvent)	[Reaction:R-SSC-804969] HSD17B1 hydrogenates E1 to EST17b
(inferredTo)	[Reaction:R-HSA-193060] CYP19A1 hydroxylates ANDST to E1

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