CYP39A1 7-hydroxylates 24OH-CHOL

Stable Identifier
R-HSA-192178
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, 24-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
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24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1), located on the ER membrane, 7-alpha-hydroxylates 24-hydroxycholesterol (24OH-CHOL) to cholest-5-ene-3beta,7alpha,24-triol (CHOL7a,24(S)DIOL). In the body, expression of CYP39A1 is restricted to the liver and is involved in bile acid metabolism (Li-Hawkins et al. 2000).

Literature References
PubMed ID Title Journal Year
10748047 Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol

Li-Hawkins, J, Lund, EG, Bronson, AD, Russell, DW

J Biol Chem 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
oxysterol 7-alpha-hydroxylase activity of CYP39A1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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