Reactome | CYP39A1 7-hydroxylates 24OH-CHOL

CYP39A1 7-hydroxylates 24OH-CHOL

Stable Identifier

R-HSA-192178

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

(24S)-hydroxycholesterol + O2 + reduced (NADPH--hemoprotein reductase) => (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase), 24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol, 24-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - Cytochrome P450 - arranged by substrate type (Homo sapiens)
      - Endogenous sterols (Homo sapiens)
        
        CYP39A1 7-hydroxylates 24OH-CHOL (Homo sapiens)
- Metabolism of lipids (Homo sapiens)
  - Metabolism of steroids (Homo sapiens)
    - Bile acid and bile salt metabolism (Homo sapiens)
      - Synthesis of bile acids and bile salts (Homo sapiens)
        
        Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
        
        CYP39A1 7-hydroxylates 24OH-CHOL (Homo sapiens)

General

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24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1), located on the ER membrane, 7-alpha-hydroxylates 24-hydroxycholesterol (24OH-CHOL) to cholest-5-ene-3beta,7alpha,24-triol (CHOL7a,24(S)DIOL). In the body, expression of CYP39A1 is restricted to the liver and is involved in bile acid metabolism (Li-Hawkins et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10748047	Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol Bronson, AD, Russell, DW, Lund, EG, Li-Hawkins, J	J Biol Chem	2000