Reactome | HMGCR dimer reduces bHMG-CoA to MVA

Schema > Reaction > Entries

HMGCR dimer reduces bHMG-CoA to MVA Show undefined attributes

authored	[InstanceEdit:191754] Jassal, B, 2007-01-24 15:15:12
catalystActivity	[CatalystActivity:191301] hydroxymethylglutaryl-CoA reductase (NADPH) activity of HMGCR dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
crossReference	[DatabaseIdentifier:12667848] RHEA:15991 [DatabaseIdentifier:9945080] RHEA:15991
dbId	191352
displayName	HMGCR dimer reduces bHMG-CoA to MVA
eventOf	[Pathway:R-HSA-9969896] Lanosterol biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-191380] Mevalonate is phosphorylated to mevalonate-5-phosphate - Homo sapiens
input	[SimpleEntity:R-ALL-191374] bHMG-CoA [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:191315] Regulation of the mevalonate pathway [LiteratureReference:191420] Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	HMGCR dimer reduces bHMG-CoA to MVA (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+) => (R)-mevalonate + 2 NADP(+) + CoA
orthologousEvent	[Reaction:R-SCE-191352] HMGCR dimer reduces bHMG-CoA to MVA - Saccharomyces cerevisiae [Reaction:R-SPO-191352] HMGCR dimer reduces bHMG-CoA to MVA - Schizosaccharomyces pombe [Reaction:R-DDI-191352] HMGCR dimer reduces bHMG-CoA to MVA - Dictyostelium discoideum [Reaction:R-CEL-191352] HMGCR dimer reduces bHMG-CoA to MVA - Caenorhabditis elegans [Reaction:R-DME-191352] HMGCR dimer reduces bHMG-CoA to MVA - Drosophila melanogaster [Reaction:R-GGA-191352] HMGCR dimer reduces bHMG-CoA to MVA - Gallus gallus [Reaction:R-XTR-191352] HMGCR dimer reduces bHMG-CoA to MVA - Xenopus tropicalis [Reaction:R-DRE-191352] HMGCR dimer reduces bHMG-CoA to MVA - Danio rerio [Reaction:R-SSC-191352] HMGCR dimer reduces bHMG-CoA to MVA - Sus scrofa [Reaction:R-BTA-191352] HMGCR dimer reduces bHMG-CoA to MVA - Bos taurus [Reaction:R-CFA-191352] HMGCR dimer reduces bHMG-CoA to MVA - Canis familiaris [Reaction:R-RNO-191352] HMGCR dimer reduces bHMG-CoA to MVA - Rattus norvegicus [Reaction:R-MMU-191352] HMGCR dimer reduces bHMG-CoA to MVA - Mus musculus
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-191424] MVA [cytosol] 2 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Homo sapiens
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:191591] D'Eustachio, P, 2007-01-22 01:32:07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-191352
summation	[Summation:191349] Dimeric 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR dime...
updateTrackers	[UpdateTracker:9971835] Update Tracker - [Reaction:191352] HMGCR dimer reduces bHMG-CoA to MVA - v95:[modifyText, removeLiteratureReference] [UpdateTracker:9776647] Update Tracker - [Reaction:191352] HMGCR dimer reduces bHMG-CoA to MVA - v75:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9971835] Update Tracker - [Reaction:191352] HMGCR dimer reduces bHMG-CoA to MVA - v95:[modifyText, removeLiteratureReference] [UpdateTracker:9776647] Update Tracker - [Reaction:191352] HMGCR dimer reduces bHMG-CoA to MVA - v75:[modifyText]
(hasEvent)	[Pathway:R-HSA-9969896] Lanosterol biosynthesis
(precedingEvent)	[Reaction:R-HSA-191380] Mevalonate is phosphorylated to mevalonate-5-phosphate