Reactome | HMGCR dimer reduces bHMG-CoA to MVA

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HMGCR dimer reduces bHMG-CoA to MVA Show undefined attributes

catalystActivity	[CatalystActivity:10745623] hydroxymethylglutaryl-CoA reductase (NADPH) activity of HMGCR dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10745625
displayName	HMGCR dimer reduces bHMG-CoA to MVA
eventOf	[Pathway:R-GGA-9969896] Lanosterol biosynthesis - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-191380] Mevalonate is phosphorylated to mevalonate-5-phosphate - Gallus gallus
inferredFrom	[Reaction:R-HSA-191352] HMGCR dimer reduces bHMG-CoA to MVA - Homo sapiens
input	[SimpleEntity:R-ALL-191374] bHMG-CoA [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HMGCR dimer reduces bHMG-CoA to MVA (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+) => (R)-mevalonate + 2 NADP(+) + CoA
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-191424] MVA [cytosol] 2 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-GGA-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-191352
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-9969896] Lanosterol biosynthesis
(precedingEvent)	[Reaction:R-GGA-191380] Mevalonate is phosphorylated to mevalonate-5-phosphate
(inferredTo)	[Reaction:R-HSA-191352] HMGCR dimer reduces bHMG-CoA to MVA

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