Reactome | HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA

Schema > Reaction > Entries

HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA Show undefined attributes

authored	[InstanceEdit:191754] Jassal, B, 2007-01-24 15:15:12
catalystActivity	[CatalystActivity:191334] hydroxymethylglutaryl-CoA synthase activity of HMGCS1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
crossReference	[DatabaseIdentifier:11880385] Rhea:10189
dbId	191323
displayName	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA
eventOf	[Pathway:R-HSA-191273] Cholesterol biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-191352] HMGCR dimer reduces bHMG-CoA to MVA - Homo sapiens
input	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] [SimpleEntity:R-ALL-191293] ACA-CoA [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:191286] Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild-type and Cys129 mutant enzymes
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA
orthologousEvent	[Reaction:R-SCE-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Saccharomyces cerevisiae [Reaction:R-SPO-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Schizosaccharomyces pombe [Reaction:R-DDI-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Dictyostelium discoideum [Reaction:R-CEL-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Caenorhabditis elegans [Reaction:R-DME-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Drosophila melanogaster [Reaction:R-GGA-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Gallus gallus [Reaction:R-SSC-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Sus scrofa [Reaction:R-BTA-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Bos taurus [Reaction:R-CFA-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Canis familiaris [Reaction:R-RNO-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Rattus norvegicus [Reaction:R-MMU-191323] HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA - Mus musculus
output	[SimpleEntity:R-ALL-191374] bHMG-CoA [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-HSA-8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA - Homo sapiens
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:191591] D'Eustachio, P, 2007-01-22 01:32:07
revised	[InstanceEdit:9735738] D'Eustachio, Peter, 2021-06-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-191323
summation	[Summation:191353] 3-hydroxy-3-methylglutaryl Coenzyme A synthase (HMG-CoA synt...

Referrals

(hasEvent)	[Pathway:R-HSA-191273] Cholesterol biosynthesis
(precedingEvent)	[Reaction:R-HSA-191352] HMGCR dimer reduces bHMG-CoA to MVA