HMGCR dimer reduces bHMG-CoA to MVA

Stable Identifier
R-HSA-191352
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Reduction of HMG-CoA produces mevalonate
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Dimeric 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR dimer) catalyzes the four-electron reduction of beta-hydroxy-beta-methylglutaryl-CoA (bHMG-CoA) to mevalonate (MVA). MVA concentrations in the cell are tightly controlled through the activity of HMGCR dimer, which is one of the most highly regulated enzymes in metabolism (Goldstein & Brown 1990).

Literature References
PubMed ID Title Journal Year
10698924 Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis

Istvan, ES, Palnitkar, M, Buchanan, SK, Deisenhofer, J

EMBO J 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hydroxymethylglutaryl-CoA reductase (NADPH) activity of HMGCR dimer [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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