HMGCR dimer reduces bHMG-CoA to MVA

Stable Identifier
R-HSA-191352
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Synonyms
Reduction of HMG-CoA produces mevalonate
ReviewStatus
5/5
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HMGCR dimer reduces bHMG-CoA to MVA
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Dimeric 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR dimer) catalyzes the four-electron reduction of beta-hydroxy-beta-methylglutaryl-CoA (bHMG-CoA) to mevalonate (MVA). MVA concentrations in the cell are tightly controlled through the activity of HMGCR dimer, which is one of the most highly regulated enzymes in metabolism (Goldstein & Brown 1990).

Literature References
PubMed ID Title Journal Year
10698924 Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis

Deisenhofer, J, Istvan, ES, Buchanan, SK, Palnitkar, M

EMBO J 2000
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Catalyst Activity

hydroxymethylglutaryl-CoA reductase (NADPH) activity of HMGCR dimer [endoplasmic reticulum membrane]

Physical Entity
HMGCR dimer [endoplasmic reticulum membrane] (Homo sapiens)
Activity
hydroxymethylglutaryl-CoA reductase (NADPH) activity (GO:0004420)
Orthologous Events
HMGCR dimer reduces bHMG-CoA to MVA (Bos taurus)
HMGCR dimer reduces bHMG-CoA to MVA (Caenorhabditis elegans)
HMGCR dimer reduces bHMG-CoA to MVA (Canis familiaris)
HMGCR dimer reduces bHMG-CoA to MVA (Danio rerio)
HMGCR dimer reduces bHMG-CoA to MVA (Dictyostelium discoideum)
HMGCR dimer reduces bHMG-CoA to MVA (Drosophila melanogaster)
HMGCR dimer reduces bHMG-CoA to MVA (Gallus gallus)
HMGCR dimer reduces bHMG-CoA to MVA (Mus musculus)
HMGCR dimer reduces bHMG-CoA to MVA (Rattus norvegicus)
HMGCR dimer reduces bHMG-CoA to MVA (Saccharomyces cerevisiae)
HMGCR dimer reduces bHMG-CoA to MVA (Schizosaccharomyces pombe)
HMGCR dimer reduces bHMG-CoA to MVA (Sus scrofa)
HMGCR dimer reduces bHMG-CoA to MVA (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2007-01-24)
Reviewed
D'Eustachio, P  (2007-01-22)
Created
Jassal, B  (2007-01-19)
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