Reactome | HMGCR dimer reduces bHMG-CoA to MVA

HMGCR dimer reduces bHMG-CoA to MVA

Stable Identifier

R-HSA-191352

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

(3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+) => (R)-mevalonate + 2 NADP(+) + CoA

ReviewStatus

5/5

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Dimeric 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR dimer) (Istvan et al. 2000) catalyzes the four-electron reduction of beta-hydroxy-beta-methylglutaryl-CoA (bHMG-CoA) to mevalonate (MVA). MVA concentrations in the cell are tightly controlled through regulation of the activity of HMGCR dimer, which is one of the most highly regulated enzymes in metabolism (Goldstein & Brown 1990).

Literature References

PubMed ID	Title	Journal	Year
10698924	Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis Istvan, ES, Palnitkar, M, Buchanan, SK, Deisenhofer, J	EMBO J	2000
1967820	Regulation of the mevalonate pathway Goldstein, JL, Brown, MS	Nature	1990