Squalene is oxidized to its epoxide

Stable Identifier
R-HSA-191299
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Squalene monooxygenase (squalene epoxidase, SE) is located on the endoplamic reticulum. It catalyzes the oxidation of squalene to squalene 2,3-epoxide. SE seems to be an important rate-limiting enzyme in cholesterol biosynthesis.

Literature References
PubMed ID Title Journal Year
10666321 Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase

Laden, BP, Tang, Y, Porter, TD

Arch Biochem Biophys 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
squalene monooxygenase activity of SQLE:FAD [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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