Reactome | Squalene is oxidized to its epoxide

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Squalene is oxidized to its epoxide Show undefined attributes

catalystActivity	[CatalystActivity:10663612] squalene monooxygenase activity of SQLE:FAD [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10663614
displayName	Squalene is oxidized to its epoxide
eventOf	[Pathway:R-XTR-9969896] Lanosterol biosynthesis - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-191299] Squalene is oxidized to its epoxide - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol] [SimpleEntity:R-ALL-191269] SQNE [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Squalene is oxidized to its epoxide squalene + reduced (NADPH--hemoprotein reductase) + O2 = (S)-2,3-epoxysqualene + oxidized (NADPH--hemoprotein reductase) + H2O + H(+)
output	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-191309] SQOX [cytosol]
precedingEvent	[Reaction:R-XTR-191402] Reduction of presqualene diphosphate to form squalene - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-191299
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9969896] Lanosterol biosynthesis
(precedingEvent)	[Reaction:R-XTR-191366] Squalene 2,3-epoxide cyclizes, forming lanosterol
(inferredTo)	[Reaction:R-HSA-191299] Squalene is oxidized to its epoxide

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