NOTCH1 mRNA translation controlled by miRNAs

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R-HSA-1912412
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Reaction [omitted]
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Homo sapiens
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Translation of NOTCH1 mRNA is negatively regulated by microRNAs miR-200B and miR200C (Kong et al. 2010), miR-34 (Li et al. 2009, Ji et al. 2009) and miR-449 (Marcet et al. 2011). These miRNAs bind and cause degradation of NOTCH1 mRNA, resulting in decreased level of NOTCH1 protein product.

Literature References
PubMed ID Title Journal Year
20805998 Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells

Kong, D, Banerjee, S, Ahmad, A, Sethi, S, Sarkar, FH, Wang, Z, Li, Y

PLoS One 2010
21602795 Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway

Marcet, B, Chevalier, B, Luxardi, G, Coraux, C, Zaragosi, LE, Cibois, M, Robbe-Sermesant, K, Jolly, T, Cardinaud, B, Moreilhon, C, Giovannini-Chami, L, Nawrocki-Raby, B, Birembaut, P, Waldmann, R, Kodjabachian, L, Barbry, P

Nat Cell Biol 2011
19773441 MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes

Li, Y, Guessous, F, Zhang, Y, DiPierro, C, Kefas, B, Johnson, E, Marcinkiewicz, L, Jiang, J, Yang, Y, Schmittgen, TD, Lopes, B, Schiff, D, Purow, B, Abounader, R

Cancer Res 2009
19714243 MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells

Ji, Q, Hao, X, Zhang, M, Tang, W, Meng, Y, Li, L, Xiang, D, DeSano, JT, Bommer, GT, Fan, D, Fearon, ER, Lawrence, TS, Xu, L

PLoS One 2009
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