NOTCH1 mRNA translation controlled by miRNAs

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Translation of NOTCH1 mRNA is negatively regulated by microRNAs miR-200B and miR200C (Kong et al. 2010), miR-34 (Li et al. 2009, Ji et al. 2009) and miR-449 (Marcet et al. 2011). These miRNAs bind and cause degradation of NOTCH1 mRNA, resulting in decreased level of NOTCH1 protein product.

Literature References
PubMed ID Title Journal Year
21602795 Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway

Moreilhon, C, Coraux, C, Robbe-Sermesant, K, Kodjabachian, L, Barbry, P, Waldmann, R, Cardinaud, B, Chevalier, B, Marcet, B, Zaragosi, LE, Jolly, T, Birembaut, P, Nawrocki-Raby, B, Cibois, M, Luxardi, G, Giovannini-Chami, L

Nat Cell Biol 2011
20805998 Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells

Li, Y, Kong, D, Sarkar, FH, Sethi, S, Wang, Z, Banerjee, S, Ahmad, A

PLoS One 2010
19773441 MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes

Guessous, F, DiPierro, C, Kefas, B, Li, Y, Schiff, D, Johnson, E, Jiang, J, Purow, B, Lopes, B, Zhang, Y, Marcinkiewicz, L, Abounader, R, Yang, Y, Schmittgen, TD

Cancer Res 2009
19714243 MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells

DeSano, JT, Lawrence, TS, Meng, Y, Fan, D, Bommer, GT, Fearon, ER, Xiang, D, Ji, Q, Tang, W, Hao, X, Zhang, M, Xu, L, Li, L

PLoS One 2009
This event is regulated