NOTCH1 mRNA translation controlled by miRNAs

Stable Identifier
R-HSA-1912412
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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NOTCH1 mRNA translation controlled by miRNAs
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Translation of NOTCH1 mRNA is negatively regulated by microRNAs miR-200B and miR200C (Kong et al. 2010), miR-34 (Li et al. 2009, Ji et al. 2009) and miR-449 (Marcet et al. 2011). These miRNAs bind and cause degradation of NOTCH1 mRNA, resulting in decreased level of NOTCH1 protein product.
Literature References
PubMed ID Title Journal Year
21602795 Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway

Moreilhon, C, Coraux, C, Robbe-Sermesant, K, Kodjabachian, L, Barbry, P, Waldmann, R, Cardinaud, B, Chevalier, B, Marcet, B, Zaragosi, LE, Jolly, T, Birembaut, P, Nawrocki-Raby, B, Cibois, M, Luxardi, G, Giovannini-Chami, L

Nat Cell Biol 2011
20805998 Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells

Li, Y, Kong, D, Sarkar, FH, Sethi, S, Wang, Z, Banerjee, S, Ahmad, A

PLoS One 2010
19773441 MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes

Guessous, F, DiPierro, C, Kefas, B, Li, Y, Schiff, D, Johnson, E, Jiang, J, Purow, B, Lopes, B, Zhang, Y, Marcinkiewicz, L, Abounader, R, Yang, Y, Schmittgen, TD

Cancer Res 2009
19714243 MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells

DeSano, JT, Lawrence, TS, Meng, Y, Fan, D, Bommer, GT, Fearon, ER, Xiang, D, Ji, Q, Tang, W, Hao, X, Zhang, M, Xu, L, Li, L

PLoS One 2009
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
NOTCH1 mRNA:miR-200B/C RISC [cytosol] (Homo sapiens)
Active Unit
miR-200B/C RISC [cytosol]
Regulator
NOTCH1 mRNA:miR-34 RISC [cytosol] (Homo sapiens)
Active Unit
miR-34 RISC [cytosol]
Regulator
NOTCH1 mRNA:miR-449 RISC [cytosol] (Homo sapiens)
Active Unit
miR-449 RISC [cytosol]
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-02)
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