Reactome | Transport of NOTCH precursor to Golgi

Transport of NOTCH precursor to Golgi

Stable Identifier

R-HSA-1912374

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

Golgi membrane, endoplasmic reticulum membrane

ReviewStatus

5/5

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NOTCH receptor precursors (Pre-NOTCH) traffic from the endoplasmic reticulum to the Golgi. Endoplasmic reticulum calcium ATPases are required for maintenance of high levels of calcium and positively regulate NOTCH trafficking, perhaps by ensuring proper NOTCH folding. Exit of NOTCH precursors from the endoplasmic reticulum is negatively regulated by SEL1L (Li et al. 2010, Sundaram et al. 1993), an endoplasmic reticulum membrane protein that is part of the ERAD (endoplasmic reticulum associated degradation) system, which performs quality control and triggers degradation of misfolded proteins (Francisco et al. 2010). NOTCH trafficking through the Golgi and trans-Golgi network is positively regulated by RAB6, a Golgi membrane GTPase. Endoplasmic reticulum calcium ATPases are required for maintenance of high levels of calcium and positively regulate NOTCH trafficking, perhaps by ensuring proper NOTCH folding.

Literature References

PubMed ID	Title	Journal	Year
10545110	Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila Fortini, ME, Periz, G	EMBO J	1999
20170518	SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells Francisco, AB, Long, Q, Schimenti, JC, Munroe, RJ, Li, S	BMC Dev Biol	2010
1295745	Notch2: a second mammalian Notch gene Roberts, VJ, Lemke, G, Weinmaster, G	Development	1992
10459009	The developmental role of warthog, the notch modifier encoding Drab6 Artavanis-Tsakonas, S, Purcell, K	J Cell Biol	1999
8681805	Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene Wu, G, Marazzi, G, Uyttendaele, H, Kitajewski, J, Yan, Q, Sassoon, D	Development	1996
20197277	Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality Singh, R, Francisco, AB, Long, Q, Yang, L, Schimenti, JC, Munroe, RJ, Qi, L, Biunno, I, Vani, AK, Cardano, M, Li, S, Diaferia, G	J Biol Chem	2010
1764995	A homolog of Drosophila Notch expressed during mammalian development Roberts, VJ, Lemke, G, Weinmaster, G	Development	1991
7918097	The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium Dahlstrand, J, Lendahl, U, Lardelli, M	Mech Dev	1994
8293978	Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans Greenwald, I, Sundaram, M	Genetics	1993
9244302	Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane Artavanis-Tsakonas, S, Zagouras, P, Qi, H, Blaumueller, CM	Cell	1997