Transport of NOTCH precursor to Golgi

Stable Identifier
R-HSA-1912374
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NOTCH receptor precursors (Pre-NOTCH) traffic from the endoplasmic reticulum to the Golgi. Endoplasmic reticulum calcium ATPases are required for maintenance of high levels of calcium and positively regulate NOTCH trafficking, perhaps by ensuring proper NOTCH folding. Exit of NOTCH precursors from the endoplasmic reticulum is negatively regulated by SEL1L (Li et al. 2010, Sundaram et al. 1993), an endoplasmic reticulum membrane protein that is part of the ERAD (endoplasmic reticulum associated degradation) system, which performs quality control and triggers degradation of misfolded proteins (Francisco et al. 2010). NOTCH trafficking through the Golgi and trans-Golgi network is positively regulated by RAB6, a Golgi membrane GTPase. Endoplasmic reticulum calcium ATPases are required for maintenance of high levels of calcium and positively regulate NOTCH trafficking, perhaps by ensuring proper NOTCH folding.

Literature References
PubMed ID Title Journal Year
10545110 Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila

Fortini, ME, Periz, G

EMBO J 1999
20170518 SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells

Francisco, AB, Long, Q, Schimenti, JC, Munroe, RJ, Li, S

BMC Dev Biol 2010
1295745 Notch2: a second mammalian Notch gene

Roberts, VJ, Lemke, G, Weinmaster, G

Development 1992
10459009 The developmental role of warthog, the notch modifier encoding Drab6

Artavanis-Tsakonas, S, Purcell, K

J Cell Biol 1999
8681805 Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

Wu, G, Marazzi, G, Uyttendaele, H, Kitajewski, J, Yan, Q, Sassoon, D

Development 1996
20197277 Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality

Singh, R, Francisco, AB, Long, Q, Yang, L, Schimenti, JC, Munroe, RJ, Qi, L, Biunno, I, Vani, AK, Cardano, M, Li, S, Diaferia, G

J Biol Chem 2010
1764995 A homolog of Drosophila Notch expressed during mammalian development

Roberts, VJ, Lemke, G, Weinmaster, G

Development 1991
7918097 The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium

Dahlstrand, J, Lendahl, U, Lardelli, M

Mech Dev 1994
8293978 Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans

Greenwald, I, Sundaram, M

Genetics 1993
9244302 Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

Artavanis-Tsakonas, S, Zagouras, P, Qi, H, Blaumueller, CM

Cell 1997
Participants
Participates
This event is regulated
Inferred From
Authored
Reviewed
Created
Cite Us!