Reactome | ITCH ubiquitinates DTX

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10598392] ubiquitin-protein transferase activity of DTX:ITCH [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10598394
displayName	ITCH ubiquitinates DTX
eventOf	[Pathway:R-DRE-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1912357] ITCH ubiquitinates DTX - Homo sapiens
input	[Complex:R-DRE-1604453] DTX:ITCH [cytosol] [DefinedSet:R-DRE-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ITCH ubiquitinates DTX
output	[Complex:R-DRE-1911536] Ub-DTX:ITCH [cytosol]
precedingEvent	[Reaction:R-DRE-1980125] ITCH binds DTX - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-1912357
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-2122948] Activated NOTCH1 Transmits Signal to the Nucleus
(inferredTo)	[Reaction:R-HSA-1912357] ITCH ubiquitinates DTX

Cite Us!