Glycosylation of Pre-NOTCH by FRINGE

Stable Identifier
Reaction [transition]
Homo sapiens
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The Fringe family (CAZy family GT31) of glycosyltransferases in mammals includes LFNG (lunatic fringe; MIM:602576), MFNG (manic fringe; MIM:602577) and RFNG (radical fringe; MIM:602578). Fringe enzymes function in the Golgi apparatus where they initiate the elongation of O-linked fucose on fucosylated peptides by the addition of a beta-1,3-N-acetylglucosaminyl group (GlcNAc) (Moloney et al. 2000). Fringe enzymes elongate conserved O fucosyl residues conjugated to EGF repeats of NOTCH, modulating NOTCH activity (Cohen et al. 1997, Johnston et al. 1997) by decreasing the affinity of NOTCH extracellular domain for JAG ligands (Bruckner et al. 2000). In developing mouse thymocytes, Lfng enhances Notch1 activation by Dll4, resulting in prolonged Notch1 signaling that promotes self-renewal of TCR-beta-expressing progenitors (Yuan et al. 2011). Since the exact preference, if any, of fringe enzymes for NOTCH O-fucose sites is not known, the extension of an O-fucosyl residue at an unknown protein position is shown.

Literature References
PubMed ID Title Journal Year
10935626 Fringe is a glycosyltransferase that modifies Notch

Shao, L, Wang, Y, Johnston, SH, Irvine, KD, Stanley, P, Haltiwanger, RS, Moloney, DJ, Wilson, R, Chen, J, Vogt, TF, Panin, VM

Nature 2000
10935637 Glycosyltransferase activity of Fringe modulates Notch-Delta interactions

Br├╝ckner, K, Cohen, S, Perez, L, Clausen, H

Nature 2000
9207795 Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila

Bashirullah, A, Whiting, E, Phillips, RA, Boulianne, G, Egan, SE, Campbell, C, Hui, CC, Zinyk, D, Dagnino, L, Fisher, WW, Lipshitz, HD, Leow, CC, Cohen, B, Ryan, D, Gallie, B

Nat Genet 1997
9187150 A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway

Prabhakaran, B, Johnston, SH, Irvine, KD, Rauskolb, C, Wilson, R, Vogt, TF

Development 1997
21097675 Lunatic Fringe prolongs Delta/Notch-induced self-renewal of committed ?? T-cell progenitors

Matei, IR, Tan, JB, Urbanellis, P, Egan, SE, Xu, K, Danska, JS, Visan, I, Yuan, JS, Guidos, CJ

Blood 2011
Catalyst Activity

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity of Fringe family [Golgi membrane]

Inferred From
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