Reactome | 2 delta-aminolevulinate => porphobilinogen + 2 H2O

Schema > Reaction > Entries

authored	[InstanceEdit:421527] D'Eustachio, P, 2009-05-18 21:56:17
catalystActivity	[CatalystActivity:421494] porphobilinogen synthase activity of ALAD octamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:421438] D'Eustachio, P, 2009-05-18 21:49:08
dbId	421472
displayName	2 delta-aminolevulinate => porphobilinogen + 2 H2O
edited	[InstanceEdit:421527] D'Eustachio, P, 2009-05-18 21:56:17
eventOf	[Pathway:R-GGA-421984] Heme synthesis - Gallus gallus
followingEvent	[Reaction:R-GGA-421439] 4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3 - Gallus gallus
inferredFrom	[Reaction:R-HSA-189439] ALAD condenses 2 dALAs to form PBG - Homo sapiens
input	2 × [SimpleEntity:R-ALL-189489] dALA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	2 delta-aminolevulinate => porphobilinogen + 2 H2O
output	2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-189464] PBG [cytosol]
precedingEvent	[BlackBoxEvent:R-GGA-421517] Transport of delta-aminolevulinate from the mitochondrial matrix to the cytosol - Gallus gallus
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-421472
summation	[Summation:421511] Cytosolic ALAD (delta-aminolevulinate dehydratase) catalyzes...

(hasEvent)	[Pathway:R-GGA-421984] Heme synthesis
(precedingEvent)	[Reaction:R-GGA-421439] 4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3
(inferredTo)	[Reaction:R-HSA-189439] ALAD condenses 2 dALAs to form PBG

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