Reactome | B3GALT6 transfers Gal to the tetrasaccharide linker

Schema > Reaction > Entries

B3GALT6 transfers Gal to the tetrasaccharide linker Show undefined attributes

authored	[InstanceEdit:1889961] Jassal, B, 2011-11-01
catalystActivity	[CatalystActivity:1889957] galactosylxylosylprotein 3-beta-galactosyltransferase activity of B3GALT6 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:1889961] Jassal, B, 2011-11-01
crossReference	[DatabaseIdentifier:9941153] RHEA:11781
dbId	1889978
diseaseReaction	[FailedReaction:R-HSA-4420365] Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker - Homo sapiens
displayName	B3GALT6 transfers Gal to the tetrasaccharide linker
edited	[InstanceEdit:1889961] Jassal, B, 2011-11-01
eventOf	[Pathway:R-HSA-1971475] Glycosaminoglycan-protein linkage region biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-1889955] B3GAT dimers transfer GlcA to tetrasaccharide linker - Homo sapiens
input	[DefinedSet:R-HSA-2064058] Gal-Xyl-proteins [Golgi lumen] [SimpleEntity:R-ALL-735682] UDP-Gal [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:977024] Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6) [LiteratureReference:1889993] A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	B3GALT6 transfers Gal to the tetrasaccharide linker A second galactose is added in the tetrasaccharide linker
orthologousEvent	[Reaction:R-BTA-1889978] B3GALT6 transfers Gal to the tetrasaccharide linker - Bos taurus [Reaction:R-CEL-1889978] B3GALT6 transfers Gal to the tetrasaccharide linker - Caenorhabditis elegans [Reaction:R-DME-1889978] B3GALT6 transfers Gal to the tetrasaccharide linker - Drosophila melanogaster [Reaction:R-GGA-1889978] B3GALT6 transfers Gal to the tetrasaccharide linker - Gallus gallus [Reaction:R-XTR-1889978] B3GALT6 transfers Gal to the tetrasaccharide linker - Xenopus tropicalis [Reaction:R-DRE-1889978] B3GALT6 transfers Gal to the tetrasaccharide linker - Danio rerio [Reaction:R-SSC-1889978] B3GALT6 transfers Gal to the tetrasaccharide linker - Sus scrofa [Reaction:R-CFA-1889978] B3GALT6 transfers Gal to the tetrasaccharide linker - Canis familiaris [Reaction:R-RNO-1889978] B3GALT6 transfers Gal to the tetrasaccharide linker - Rattus norvegicus [Reaction:R-MMU-1889978] B3GALT6 transfers Gal to the tetrasaccharide linker - Mus musculus
output	[DefinedSet:R-HSA-2064214] Gal-Gal-Xyl-proteins [Golgi lumen] [SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[Reaction:R-HSA-1889981] B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker - Homo sapiens [Reaction:R-HSA-735702] SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1889978
summation	[Summation:1889951] Beta-1,3-galactosyltransferase 6 (B3GALT6) transfers a secon...
updateTrackers	[UpdateTracker:9953651] Update Tracker - [Reaction:1889978] B3GALT6 transfers Gal to the tetrasaccharide linker - v93:[removeOutput] [UpdateTracker:9787050] Update Tracker - [Reaction:1889978] B3GALT6 transfers Gal to the tetrasaccharide linker - v46:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9953651] Update Tracker - [Reaction:1889978] B3GALT6 transfers Gal to the tetrasaccharide linker - v93:[removeOutput] [UpdateTracker:9787050] Update Tracker - [Reaction:1889978] B3GALT6 transfers Gal to the tetrasaccharide linker - v46:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-4420365] Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker
(hasEvent)	[Pathway:R-HSA-1971475] Glycosaminoglycan-protein linkage region biosynthesis
(precedingEvent)	[Reaction:R-HSA-1889955] B3GAT dimers transfer GlcA to tetrasaccharide linker

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