Reactome | B3GALT6 transfers Gal to the tetrasaccharide linker

B3GALT6 transfers Gal to the tetrasaccharide linker

Stable Identifier

R-HSA-1889978

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

Synonyms

A second galactose is added in the tetrasaccharide linker

ReviewStatus

5/5

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B3GALT6 transfers Gal to the tetrasaccharide linker

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Beta-1,3-galactosyltransferase 6 (B3GALT6) transfers a second galactose to the tetrasaccharide linker. Although it can act on substrates with a terminal beta-linked galactose residue, it prefers the sequence galactose-beta-1,4-xylose (Bai et al. 2001). B3GALT6 requires manganese as a cofactor (Zhou et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
11551958	Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6) Bai, X, Zhou, D, Brown, JR, Crawford, BE, Hennet, T, Esko, JD	J Biol Chem	2001
9892646	A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases Zhou, D, Dinter, A, Gutiérrez Gallego, R, Kamerling, JP, Vliegenthart, JF, Berger, EG, Hennet, T	Proc Natl Acad Sci U S A	1999