B3GALT6 transfers Gal to the tetrasaccharide linker

Stable Identifier
R-HSA-1889978
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, Golgi lumen
Synonyms
A second galactose is added in the tetrasaccharide linker
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B3GALT6 transfers Gal to the tetrasaccharide linker
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Beta-1,3-galactosyltransferase 6 (B3GALT6) transfers a second galactose to the tetrasaccharide linker. Although it can act on substrates with a terminal beta-linked galactose residue, it prefers the sequence galactose-beta-1,4-xylose (Bai et al. 2001). B3GALT6 requires manganese as a cofactor (Zhou et al. 1999).

Literature References
PubMed ID Title Journal Year
9892646 A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases

Zhou, D, Dinter, A, Gutiérrez Gallego, R, Kamerling, JP, Vliegenthart, JF, Berger, EG, Hennet, T

Proc Natl Acad Sci U S A 1999
11551958 Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6)

Bai, X, Zhou, D, Brown, JR, Crawford, BE, Hennet, T, Esko, JD

J Biol Chem 2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
galactosylxylosylprotein 3-beta-galactosyltransferase activity of B3GALT6 [Golgi membrane]
Physical Entity
B3GALT6 [Golgi membrane]
Activity
galactosylxylosylprotein 3-beta-galactosyltransferase activity (0047220)
Orthologous Events
B3GALT6 transfers Gal to the tetrasaccharide linker (Bos taurus)
B3GALT6 transfers Gal to the tetrasaccharide linker (Caenorhabditis elegans)
B3GALT6 transfers Gal to the tetrasaccharide linker (Danio rerio)
B3GALT6 transfers Gal to the tetrasaccharide linker (Drosophila melanogaster)
B3GALT6 transfers Gal to the tetrasaccharide linker (Mus musculus)
B3GALT6 transfers Gal to the tetrasaccharide linker (Rattus norvegicus)
B3GALT6 transfers Gal to the tetrasaccharide linker (Sus scrofa)
B3GALT6 transfers Gal to the tetrasaccharide linker (Xenopus tropicalis)
Authored
Jassal, B  (2011-11-01)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-11-01)
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